代表性文章
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"Single-cell whole-genome analyses by Linear Amplification via Transposon Insertion (LIANTI)" Science 356, 189-194. (2017) | |
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"Live births after simultaneous avoidance of monogenic diseases and chromosome abnormality by next-generation sequencing with linkage analyses" PNAS 112(52), 15964-15969 (2015). | |
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"Reproducible copy number variation patterns among single circulating tumor cells of lung cancer patients" PNAS 110, 21083-21088 (2013). | |
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"Genome Analyses of Single Human Oocytes" Cell 155, 1492-1506 (2013). | |
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"Genome-Wide Detection of Single-Nucleotide and Copy-Number Variations of a Single Human Cell" Science 338, 1622-1626 (2012). | |
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"Probing Meiotic Recombination and Aneuploidy of Single Sperm Cells by Whole-Genome Sequencing" Science 338, 1627-1630 (2012). | |
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"Digital RNA Sequencing Minimizes Sequence-dependent Bias and Amplification Noise with Optimized Single-molecule Barcodes," PNAS 109, 1347-1352 (2012). | |
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"Fluorogenic DNA Sequencing in PDMS Microreactors," Nat Methods 8, 575-580 (2011). |
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Coherent Raman Microscopy |
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"Rapid, Label-Free Detection of Brain Tumors with Stimulated Raman Scattering Microscopy," Science Translational Medicine 5, 201ra119 DOI: 10.1126/scitranslmed.3005954 (2013) | |
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"RNAi Screening for Fat Regulatory Genes with SRS Microscopy," Nat Methods 8, 135-138 (2011). |
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"Video-Rate Molecular Imaging in Vivo with Stimulated Raman Scattering," Science 330, 1368-1370 (2010). |
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"Label-Free Biomedical Imaging with High sensitivity by Stimulated Raman Scattering Microscopy," Science 322, 1857-1860 (2008). |
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"Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy" Proc Nat. Aca Sci 102, 16807-16812 (2005). |
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'Vibrational Microscopy Using Coherent Anti-Stokes Raman Scattering," Phys Rev Lett 82, 4142-4145 (1999). |
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Gene Expression and Regulation - Live Cell Single Molecule Studies |
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"Quantifying E. coli Proteome and Transcriptome with Single-Molecule Sensitivity in Single Cells," Science 329, 533-538 (2010). |
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"A Stochastic Single-Molecule Event Triggers Phenotype Switching of a Bacterial Cell," Science 322, 442-446 (2008). |
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"Probing Transcription Factor Dynamics at the Single-Molecule Level in a Living Cell," Science 316, 1191-1194 (2007). |
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"Probing Gene Expression in Live Cells, One Protein Molecule at a Time," Science 311, 1600-1603 (2006). |
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"Stochastic Protein Expression in Individual Cells at the Single Molecule Level," Nature 440, 358-362 (2006). |
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Single Molecule Enzymology |
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"Mechanism of Transcriptional Bursting in Bacteria" Cell 158, 314-326 (2014). | |
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"Probing Allostery Through DNA" Science 339, 816-819 (2013) |
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"Ever-Fluctuating Single Enzyme Molecules: Michaelis-Menten Equation Revisited," Nat Chem Bio 2, 87-94 (2006). |
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"Protein Conformational Dynamics Probed by Single-Molecule Electron Transfer," Science 302, 262-266 (2003). |
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"Single-Molecule Enzymatic Dynamics," Science 282, 1877-1882 (1998). |
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Single Molecule Spectroscopy and Imaging |
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"Ground-State Depletion Microscopy:Detection Sensitivity of Single-Molecule Optical Absorption at Room Temperature,"J Phys Chem Lett 1, 3316-3322 (2010). |
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"Imaging Chromophores with Undetectable Fluorescence by Stimulated Emission Microscopy," Nature 461, 1105-1109 (2009). |
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"Near-field Fluorescence Microscopy Based on Two-photon Excitation with Metal Tips," Phys Rev Lett 82, 4014-4017 (1999). |
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"Single-Molecule Spectral Fluctuations at Room Temperature," Nature 385, 143-146 (1997). | |
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"Room-Temperature Fluorescence Imaging and Spectroscopy of Single Molecules by Two-Photon Excitation," J Phys Chem A 101, 7019-7023 (1997). |
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"Probing Single Molecule Dynamics," Science 265, 361-364 (1994). |