Publications

Taniguchi, Yuichi; Choi, Paul J.; Li, Gene-Wei; Chen, Huiyi; Babu, Mohan; Hearn, Jeremy; Emili, Andrew; Xie, X. Sunney "Quantifying E. coli Proteome and Transcriptome with Single-Molecule Sensitivity in Single Cells," Science 329(5991), 533-538 DOI: 10.1126/science.1188308 (2010)
Saar, B. G.; Freudiger, C. W.; Reichman, J.; Stanley, C. M.; Holtom, G. R.; Xie, X. S. "Video-Rate Molecular Imaging in Vivo with Stimulated Raman Scattering," Science 330(6009), 1368-1370 DOI: 10.1126/science.1197236 (2010)
Chong, Shasha; Min, Wei; Xie, X. Sunney "Ground-State Depletion Microscopy: Detection Sensitivity of Single-Molecule Optical Absorption at Room Temperature," The Journal of Physical Chemistry Letters 1(23), 3316-3322 DOI: 10.1021/jz1014289 (2010)
Wang, Ke; Freudiger, Christian W.; Lee, Jennifer H.; Saar, Brian G.; Xie, X. Sunney; Xu, Chris "Synchronized time-lens source for coherent Raman scattering microscopy," Optics Express 18(23), 24019 DOI: 10.1364/oe.18.024019 (2010)
Xie, X. S. "Single Molecule Spectroscopy in Chemistry, Physics and Biology," Springer Series in Chemical Physics DOI: 10.1007/978-3-642-02597-6 (2010)
Choi, Paul J.; Xie, X. Sunney; Shakhnovich, Eugene I. "Stochastic Switching in Gene Networks Can Occur by a Single-Molecule Event or Many Molecular Steps," Journal of Molecular Biology 396(1), 230-244 DOI: 10.1016/j.jmb.2009.11.035 (2009)
Saar, Brian G.; Zeng, Yining; Freudiger, Christian W.; Liu, Yu-San; Himmel, Michael E.; Xie, X. Sunney; Ding, Shi-You "Label-Free, Real-Time Monitoring of Biomass Processing with Stimulated Raman Scattering Microscopy," Angewandte Chemie International Edition 49(32), 5476-5479 DOI: 10.1002/anie.201000900 (2010)
Min, Wei; Jiang, Liang; Xie, X. Sunney "Complex Kinetics of Fluctuating Enzymes: Phase Diagram Characterization of a Minimal Kinetic Scheme," Chemistry - An Asian Journal 5(5), 1129-1138 DOI: 10.1002/asia.200900627 (2010)
Lu, Sijia; Min, Wei; Chong, Shasha; Holtom, Gary R.; Xie, X. Sunney "Label-free imaging of heme proteins with two-photon excited photothermal lens microscopy," Applied Physics Letters 96(11), 113701 DOI: 10.1063/1.3308485 (2010)
Zeng, Yining; Saar, Brian G.; Friedrich, Marcel G.; Chen, Fang; Liu, Yu-San; Dixon, Richard A.; Himmel, Michael E.; Xie, X. Sunney; Ding, Shi-You "Imaging Lignin-Downregulated Alfalfa Using Coherent Anti-Stokes Raman Scattering Microscopy," Bioenerg. Res. 3(3), 272-277 DOI: 10.1007/s12155-010-9079-1 (2010)
Kim, Sangjin; Schroeder, Charles M.; Xie, X. Sunney "Single-Molecule Study of DNA Polymerization Activity of HIV-1 Reverse Transcriptase on DNA Templates," Journal of Molecular Biology 395(5), 995-1006 DOI: 10.1016/j.jmb.2009.11.072 (2010)
Freudiger, Christian W.; Min, Wei; Saar, Brian G.; Xie, X. Sunney "Stimulated Raman Scattering Microscopy for Label-Free Chemical Imaging," Optics & Photonics News 20(12), 30 DOI: 10.1364/opn.20.12.000030 (2009)
Blainey, Paul C; Luo, Guobin; Kou, S C; Mangel, Walter F; Verdine, Gregory L; Bagchi, Biman; Xie, X Sunney "Nonspecifically bound proteins spin while diffusing along DNA," Nature Structural & Molecular Biology 16(12), 1224-1229 DOI: 10.1038/nsmb.1716 (2009)
Lu, Ju; Min, Wei; Conchello, José-Angel; Xie, Xiaoliang Sunney; Lichtman, Jeff W. "Super-Resolution Laser Scanning Microscopy through Spatiotemporal Modulation," Nano Lett. 9(11), 3883-3889 DOI: 10.1021/nl902087d (2009)
Min, Wei; Lu, Sijia; Chong, Shasha; Roy, Rahul; Holtom, Gary R.; Xie, X. Sunney "Imaging chromophores with undetectable fluorescence by stimulated emission microscopy," Nature 461(7267), 1105-1109 DOI: 10.1038/nature08438 (2009)
Lyn, Rodney K.; Kennedy, David C.; Sagan, Selena M.; Blais, David R.; Rouleau, Yanouchka; Pegoraro, Adrian F.; Xie, X. Sunney; Stolow, Albert; Pezacki, John Paul "Direct imaging of the disruption of hepatitis C virus replication complexes by inhibitors of lipid metabolism," Virology 394(1), 130-142 DOI: 10.1016/j.virol.2009.08.022 (2009)
Min, Wei; Xie, X. Sunney; Bagchi, Biman "Role of conformational dynamics in kinetics of an enzymatic cycle in a nonequilibrium steady state," J. Chem. Phys. 131(6), 065104 DOI: 10.1063/1.3207274 (2009)
Sims, Peter A.; Xie, X. Sunney "Probing Dynein and Kinesin Stepping with Mechanical Manipulation in a Living Cell," ChemPhysChem 10(9-10), 1511-1516 DOI: 10.1002/cphc.200900113 (2009)
Saar, Brian G.; Holtom, Gary R.; Freudiger, Christian W.; Ackermann, Chrisita; Hill, Winfield; Xie, X. Sunney "Intracavity wavelength modulation of an optical parametric oscillator for coherent Raman microscopy," Optics Express 17(15), 12532 DOI: 10.1364/oe.17.012532 (2009)
Kieu, Khanh; Saar, Brian G.; Holtom, Gary R.; Xie, X. Sunney; Wise, Frank W. "High-power picosecond fiber source for coherent Raman microscopy," Opt. Lett. 34(13), 2051 DOI: 10.1364/ol.34.002051 (2009)
Min, Wei; Lu, Sijia; Rueckel, Markus; Holtom, Gary R.; Xie, X. Sunney "Near-Degenerate Four-Wave-Mixing Microscopy," Nano Lett. 9(6), 2423-2426 DOI: 10.1021/nl901101g (2009)
Min, Wei; Lu, Sijia; Holtom, Gary R.; Xie, X. Sunney "Triple-Resonance Coherent Anti-Stokes Raman Scattering Microspectroscopy," ChemPhysChem 10(2), 344-347 DOI: 10.1002/cphc.200800502 (2009)
Murugkar, S.; Evans, C. L.; Xie, X. S.; Anis, H. "Chemically specific imaging of cryptosporidium oocysts using coherent anti-Stokes Raman scattering (CARS) microscopy," Journal of Microscopy 233(2), 244-250 DOI: 10.1111/j.1365-2818.2009.03114.x (2009)
Freudiger, C. W.; Min, W.; Saar, B. G.; Lu, S.; Holtom, G. R.; He, C.; Tsai, J. C.; Kang, J. X.; Xie, X. S. "Label-Free Biomedical Imaging with High Sensitivity by Stimulated Raman Scattering Microscopy," Science 322(5909), 1857-1861 DOI: 10.1126/science.1165758 (2008)
Choi, P. J.; Cai, L.; Frieda, K.; Xie, X. S. "A Stochastic Single-Molecule Event Triggers Phenotype Switching of a Bacterial Cell," Science 322(5900), 442-446 DOI: 10.1126/science.1161427 (2008)
Xie, X. Sunney; Choi, Paul J.; Li, Gene-Wei; Lee, Nam Ki; Lia, Giuseppe "Single-Molecule Approach to Molecular Biology in Living Bacterial Cells," Annual Review of Biophysics 37(1), 417-444 DOI: 10.1146/annurev.biophys.37.092607.174640 (2008)
Evans, Conor L.; Xie, X. Sunney "Coherent Anti-Stokes Raman Scattering Microscopy: Chemical Imaging for Biology and Medicine," Annual Review of Analytical Chemistry 1(1), 883-909 DOI: 10.1146/annurev.anchem.1.031207.112754 (2008)
Nan, Xiaolin; Sims, Peter A.; Xie, X. Sunney "Organelle Tracking in a Living Cell with Microsecond Time Resolution and Nanometer Spatial Precision," ChemPhysChem 9(5), 707-712 DOI: 10.1002/cphc.200700839 (2008)
Li, J. J.; Chu, Y.; Lee, B. Y.-H.; Xie, X. S. "Enzymatic signal amplification of molecular beacons for sensitive DNA detection," Nucleic Acids Research 36(6), e36-e36 DOI: 10.1093/nar/gkn033 (2008)
Bagchi, Biman; Blainey, Paul C.; Xie, X. Sunney " Diffusion Constant of a Nonspecifically Bound Protein Undergoing Curvilinear Motion along DNA," J. Phys. Chem. B 112(19), 6282-6284 DOI: 10.1021/jp077568f (2008)
Min, Wei; Xie, X. Sunney; Bagchi, Biman " Two-Dimensional Reaction Free Energy Surfaces of Catalytic Reaction: Effects of Protein Conformational Dynamics on Enzyme Catalysis † ," J. Phys. Chem. B 112(2), 454-466 DOI: 10.1021/jp076533c (2008)
Wright, A. J.; Poland, S. P.; Girkin, J. M.; Freudiger, C. W.; Evans, C. L.; Xie, X. S. "Adaptive optics for enhanced signal in CARS microscopy," Optics Express 15(26), 18209 DOI: 10.1364/oe.15.018209 (2007)
Saar, Brian G.; Park, Heung-Shik; Xie, X. S.; Lavrentovich, Oleg D. "Three-dimensional imaging of chemical bond orientation in liquid crystals by coherent anti- Stokes Raman scattering microscopy," Optics Express 15(21), 13585 DOI: 10.1364/oe.15.013585 (2007)
Evans, Conor L.; Xu, Xiaoyin; Kesari, Santosh; Xie, X. Sunney; Wong, Stephen T.C.; Young, Geoffrey S. "Chemically-selective imaging of brain structures with CARS microscopy," Optics Express 15(19), 12076 DOI: 10.1364/oe.15.012076 (2007)
Luo, G.; Wang, M.; Konigsberg, W. H.; Xie, X. S. "Single-molecule and ensemble fluorescence assays for a functionally important conformational change in T7 DNA polymerase," Proceedings of the National Academy of Sciences 104(31), 12610-12615 DOI: 10.1073/pnas.0700920104 (2007)
Kim, Sangjin; Blainey, Paul C; Schroeder, Charles M; Xie, X Sunney "Multiplexed single-molecule assay for enzymatic activity on flow-stretched DNA," Nature Methods 4, 397-399 DOI: 10.1038/nmeth1037 (2007)
Elf, J.; Li, G.-W.; Xie, X. S. "Probing Transcription Factor Dynamics at the Single-Molecule Level in a Living Cell," Science 316(5828), 1191-1194 DOI: 10.1126/science.1141967 (2007)
Friedman, Nir; Cai, Long; Xie, X. Sunney "Linking Stochastic Dynamics to Population Distribution: An Analytical Framework of Gene Expression," Physical Review Letters 97(16) DOI: 10.1103/physrevlett.97.168302 (2006)
Min, Wei; Gopich, Irina V.; English, Brian P.; Kou, S. C.; Xie, X. Sunney; Szabo, Attila "When Does the Michaelis−Menten Equation Hold for Fluctuating Enzymes?," J. Phys. Chem. B 110(41), 20093-20097 DOI: 10.1021/jp065187g (2006)
Qian, Hong; Sunney Xie, X. "Generalized Haldane equation and fluctuation theorem in the steady-state cycle kinetics of single enzymes," Phys. Rev. E 74(1) DOI: 10.1103/physreve.74.010902 (2006)
Nan, Xiaolin; Potma, Eric O.; Xie, X. Sunney "Nonperturbative Chemical Imaging of Organelle Transport in Living Cells with Coherent Anti-Stokes Raman Scattering Microscopy," Biophysical Journal 91(2), 728-735 DOI: 10.1529/biophysj.105.074534 (2006)
Luo, Guobin; Andricioaei, Ioan; Xie, X. Sunney; Karplus, Martin "Dynamic Distance Disorder in Proteins Is Caused by Trapping," J. Phys. Chem. B 110(19), 9363-9367 DOI: 10.1021/jp057497p (2006)
Ganikhanov, Feruz; Evans, Conor L.; Saar, Brian G.; Xie, X. Sunney "High-sensitivity vibrational imaging with frequency modulation coherent anti-Stokes Raman scattering (FM CARS) microscopy," Opt. Lett. 31(12), 1872 DOI: 10.1364/ol.31.001872 (2006)
Nan, Xiaolin; Tonary, Angela M; Stolow, Albert; Xie, X. Sunney; Pezacki, John P "Intracellular Imaging of HCV RNA and Cellular Lipids by Using Simultaneous Two-Photon Fluorescence and Coherent Anti-Stokes Raman Scattering Microscopies," ChemBioChem 7, 1895-1897 DOI: (2006)
Légaré, François; Evans, Conor L.; Ganikhanov, Feruz; Xie, X. S. "Towards CARS Endoscopy," Optics Express 14(10), 4427 DOI: 10.1364/oe.14.004427 (2006)
Ganikhanov, Feruz; Carrasco, Silvia; Sunney Xie, X.; Katz, Mordechai; Seitz, Wolfgang; Kopf, Daniel "Broadly tunable dual-wavelength light source for coherent anti-Stokes Raman scattering microscopy," Opt. Lett. 31(9), 1292 DOI: 10.1364/ol.31.001292 (2006)
Xie, X. S. "Living Cells as Test Tubes," Science 312(5771), 228-230 DOI: 10.1126/science.1127566 (2006)
Blainey, P. C.; van Oijen, A. M.; Banerjee, A.; Verdine, G. L.; Xie, X. S. "A base-excision DNA-repair protein finds intrahelical lesion bases by fast sliding in contact with DNA," Proceedings of the National Academy of Sciences 103(15), 5752-5757 DOI: 10.1073/pnas.0509723103 (2006)
Lee, Jong-Bong; Hite, Richard K.; Hamdan, Samir M.; Sunney Xie, X.; Richardson, Charles C.; van Oijen, Antoine M. "DNA primase acts as a molecular brake in DNA replication," Nature 439(7076), 621-624 DOI: 10.1038/nature04317 (2006)
Rakic, Bojana; Sagan, Selena M.; Noestheden, Matthew; Bélanger, Sylvie; Nan, Xiaolin; Evans, Conor L.; Xie, X. Sunney; Pezacki, John Paul "Peroxisome Proliferator-Activated Receptor α Antagonism Inhibits Hepatitis C Virus Replication," Chemistry & Biology 13(1), 23-30 DOI: 10.1016/j.chembiol.2005.10.006 (2006)
Yu, Ji; Xiao, Jie; Lao, Kaiqin; Xie, X. Sunney "Probing Gene Expression in Live Cells, One Protein Molecule at a Time," Science 311(5767), 1600-1603 DOI: 10.1126/science.1119623 (2006)
Cai, Long; Friedman, Nir; Xie, X. Sunney "Stochastic protein expression in individual cells at the single molecule level," Nature 440(7082), 358-362 DOI: 10.1038/nature04599 (2006)
Min, Wei; Xie, X. Sunney "Kramers model with a power-law friction kernel: Dispersed kinetics and dynamic disorder of biochemical reactions," Phys. Rev. E 73(1) DOI: 10.1103/physreve.73.010902 (2006)
English, Brian P; Min, Wei; van Oijen, Antoine M; Lee, Kang Taek; Luo, Guobin; Sun, Hongye; Cherayil, Binny J; Kou, S C; Xie, X Sunney "Ever-fluctuating single enzyme molecules: Michaelis-Menten equation revisited," Nat Chem Biol 2(2), 87-94 DOI: 10.1038/nchembio759 (2006)
Potma, Eric O.; Evans, Conor L.; Xie, X. Sunney "Heterodyne coherent anti-Stokes Raman scattering (CARS) imaging," Opt. Lett. 31(2), 241 DOI: 10.1364/ol.31.000241 (2006)
Nan, Xiaolin; Sims, Peter A.; Chen, Peng; Xie, X. Sunney "Observation of Individual Microtubule Motor Steps in Living Cells with Endocytosed Quantum Dots," J. Phys. Chem. B 109(51), 24220-24224 DOI: 10.1021/jp056360w (2005)
Min, Wei; Jiang, Liang; Yu, Ji; Kou, S. C.; Qian, Hong; Xie, X. Sunney "Nonequilibrium Steady State of a Nanometric Biochemical System: Determining the Thermodynamic Driving Force from Single Enzyme Turnover Time Traces," Nano Lett. 5(12), 2373-2378 DOI: 10.1021/nl0521773 (2005)
Min, Wei; English, Brian P.; Luo, Guobin; Cherayil, Binny J.; Kou, S. C.; Xie, X. Sunney "Fluctuating Enzymes: Lessons from Single-Molecule Studies," Acc. Chem. Res. 38(12), 923-931 DOI: 10.1021/ar040133f (2005)
Debnath, Pallavi; Min, Wei; Xie, X. Sunney; Cherayil, Binny J. "Multiple time scale dynamics of distance fluctuations in a semiflexible polymer: A one-dimensional generalized Langevin equation treatment," J. Chem. Phys. 123(20), 204903 DOI: 10.1063/1.2109809 (2005)
Evans, C. L.; Potma, E. O.; Puoris'haag, M.; Cote, D.; Lin, C. P.; Xie, X. S. "Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy," Proceedings of the National Academy of Sciences 102(46), 16807-16812 DOI: 10.1073/pnas.0508282102 (2005)
Kou, S. C.; Cherayil, Binny J.; Min, Wei; English, Brian P.; Xie, X. Sunney "Single-Molecule Michaelis−Menten Equations," J. Phys. Chem. B 109(41), 19068-19081 DOI: 10.1021/jp051490q (2005)
Krug, John T.; Sánchez, Erik J.; Xie, X. Sunney "Fluorescence quenching in tip-enhanced nonlinear optical microscopy," Applied Physics Letters 86(23), 233102 DOI: 10.1063/1.1935769 (2005)
Potma, Eric O.; Xie, X. Sunney "Direct Visualization of Lipid Phase Segregation in Single Lipid Bilayers with Coherent Anti-Stokes Raman Scattering Microscopy," ChemPhysChem 6(1), 77-79 DOI: 10.1002/cphc.200400390 (2005)
Kou, S. C.; Sunney Xie, X.; Liu, Jun S. "Bayesian analysis of single-molecule experimental data (with discussion)," Journal of the Royal Statistical Society: Series C (Applied Statistics) 54(3), 469-506 DOI: 10.1111/j.1467-9876.2005.00509.x (2005)
Min, Wei; Luo, Guobin; Cherayil, Binny J.; Kou, S. C.; Xie, X. Sunney "Observation of a Power-Law Memory Kernel for Fluctuations within a Single Protein Molecule," Physical Review Letters 94(19) DOI: 10.1103/physrevlett.94.198302 (2005)
Evans, Conor L.; Potma, Eric O.; Xie, X. Sunney "Coherent anti-Stokes Raman scattering spectral interferometry: determination of the real and imaginary components of nonlinear susceptibility χ^(3) for vibrational microscopy," Opt. Lett. 29(24), 2923 DOI: 10.1364/ol.29.002923 (2004)
Potma, Eric O.; Xie, X. Sunney "CARS Microscopy for Biology and Medicine," Optics & Photonics News 15(11), 40 DOI: 10.1364/opn.15.11.000040 (2004)
Kou, S. C.; Xie, X. Sunney "Generalized Langevin Equation with Fractional Gaussian Noise: Subdiffusion within a Single Protein Molecule," Physical Review Letters 93(18) DOI: 10.1103/physrevlett.93.180603 (2004)
Potma, Eric O.; Xie, X. Sunney; Muntean, Ligia; Preusser, Jan; Jones, David; Ye, Jun; Leone, Stephen R.; Hinsberg, William D.; Schade, Wolfgang "Chemical Imaging of Photoresists with Coherent Anti-Stokes Raman Scattering (CARS) Microscopy," J. Phys. Chem. B 108(4), 1296-1301 DOI: 10.1021/jp030903p (2004)
Cheng, Ji-Xin; Xie, X. Sunney "Coherent Anti-Stokes Raman Scattering Microscopy: Instrumentation, Theory, and Applications," J. Phys. Chem. B 108(3), 827-840 DOI: 10.1021/jp035693v (2004)
Cotlet, M.; Masuo, S.; Luo, G.; Hofkens, J.; Van der Auweraer, M.; Verhoeven, J.; Mullen, K.; Xie, X. S.; De Schryver, F. "Probing conformational dynamics in single donor-acceptor synthetic molecules by means of photoinduced reversible electron transfer," Proceedings of the National Academy of Sciences 101(40), 14343-14348 DOI: 10.1073/pnas.0406119101 (2004)
Nan, Xiaolin; Yang, Wei Yuan; Xie, X. Sunney "CARS Microscopy: Lights Up Lipids in Living Cells," Biophotonics International 11(44) DOI: (2004)
Rech, I.; Luo, G.; Ghioni, M.; Yang, H.; Xie, X.S.; Cova, S. "Photon-Timing Detector Module for Single-Molecule Spectroscopy With 60-ps Resolution," IEEE Journal of Selected Topics in Quantum Electronics 10(4), 788-795 DOI: 10.1109/jstqe.2004.833975 (2004)
Louie, Tai Man; Xie, X. Sunney; Xun, Luying " Coordinated Production and Utilization of FADH 2 by NAD(P)H−Flavin Oxidoreductase and 4-Hydroxyphenylacetate 3-Monooxygenase † ," Biochemistry 42(24), 7509-7517 DOI: 10.1021/bi034092r (2003)
Dufresne, E. R.; Corwin, E. I.; Greenblatt, N. A.; Ashmore, J.; Wang, D. Y.; Dinsmore, A. D.; Cheng, J. X.; Xie, X. S.; Hutchinson, J. W.; Weitz, D. A. "Flow and Fracture in Drying Nanoparticle Suspensions," Physical Review Letters 91(22) DOI: 10.1103/physrevlett.91.224501 (2003)
Pautot, Sophie; Frisken, Barbara J.; Cheng, Ji-Xin; Xie, X. Sunney; Weitz, D. A. "Spontaneous Formation of Lipid Structures at Oil/Water/Lipid Interfaces," Langmuir 19(24), 10281-10287 DOI: 10.1021/la034532f (2003)
Nan, X.; Cheng, Ji-Xin; Xie, X. Sunney Xie "Vibrational imaging of lipid droplets in live fibroblast cells with coherent anti-Stokes Raman scattering microscopy," The Journal of Lipid Research 44(11), 2202-2208 DOI: 10.1194/jlr.d300022-jlr200 (2003)
Yang, Haw; Luo, Guobin; Karnchanaphanurach, Pallop; Louie, Tai-Man; Rech, Ivan; Cova, Sergio; Xun, Luying; Xie, X. Sunney "Protein Conformational Dynamics Probed by Single-Molecule Electron Transfer," Science 302(5643), 262-266 DOI: 10.1126/science.1086911 (2003)
Potma, Eric O.; Xie, X. S. "Detection of single lipid bilayers with coherent anti-Stokes Raman scattering (CARS) microscopy," Journal of Raman Spectroscopy 34(9), 642-650 DOI: 10.1002/jrs.1045 (2003)
Potma, Eric O.; Evans, Conor; Xie, X. Sunney; Jones, R. Jason; Ye, Jun "Picosecond-pulse amplification with an external passive optical cavity," Opt. Lett. 28(19), 1835 DOI: 10.1364/ol.28.001835 (2003)
van Oijen, Antoine M.; Blainey, Paul C.; Crampton, Donald J.; Richardson, Charles C.; Ellenberger, Tom; Xie, X. Sunney "Single-Molecule Kinetics of Exonuclease Reveal Base Dependence and Dynamic Disorder," Science 301(5637), 1235-1238 DOI: 10.1126/science.1084387 (2003)
Cheng, J.-X.; Pautot, S.; Weitz, D. A.; Xie, X. S. "Ordering of water molecules between phospholipid bilayers visualized by coherent anti-Stokes Raman scattering microscopy," Proceedings of the National Academy of Sciences 100(17), 9826-9830 DOI: 10.1073/pnas.1732202100 (2003)
Hartschuh, Achim; Sánchez, Erik J.; Xie, X. Sunney; Novotny, Lukas "High-Resolution Near-Field Raman Microscopy of Single-Walled Carbon Nanotubes," Physical Review Letters 90(9) DOI: 10.1103/physrevlett.90.095503 (2003)
Yang, Haw; Xie, X. Sunney "Probing single-molecule dynamics photon by photon," J. Chem. Phys 117, 10965 DOI: (2002)
Xie, X. Sunney "Single-molecule approach to dispersed kinetics and dynamic disorder: Probing conformational fluctuation and enzymatic dynamics," J. Chem. Phys 117, 11024 DOI: (2002)
Yang, Haw; Xie, X. Sunney "Probing Single Molecule Dynamics Photon by Photon," J. Chem. Phys 117, 10965 DOI: (2002)
Sánchez, Eric J; Krug, John T. II; Xie, X. Sunney "Ion and Electron Beam Assisted Growth of Nanometeric SimOn Structures for Near-Field Microscopy," Rev. Sci. Instr 73, 3901 DOI: (2002)
Luoie, Tai Man; Yang, Haw; Karnchanaphanurach, Pallop; Xie, X. Sunney; Xun, Luying "FAD is a Preferred Substrate and an Inhibitor of Escherichia coli General NAD(P)H: flavin Oxidoreductase," J. Biol. Chem 277, 39450 DOI: (2002)
Yang, Haw; Xie, X. Sunney "Statistical Approaches for Probing Single-molecule Dynamics Photon-by-Photon," Chem. Phys 284, 423 DOI: (2002)
Cheng, Ji-Xin; Volkmer, Andreas; Book, Lewis D; Xie, X. Sunney "Multiplex Coherent Anti-Stokes Raman Scattering Microspectroscopy and Study of Lipid Vesicles," J. Phys. Chem. B 106, 8493 DOI: (2002)
Cheng, Ji-Xin; Potma, Eric O; Xie, X. Sunney "Coherent Anti-Stokes Raman Scattering Correlation Spectroscopy: Probing Dynamical Processes with Chemical Selectivity," J. Phys. Chem. A 106, 8561 DOI: (2002)
Jones, David J; Potma, Eric O; Cheng, Ji-Xin; Burfeindt, Berndt; Pang, Yang; Ye, Jun; Xie, X. Sunney "Synchronization of two passively mode-locked, picosecond lasers within 20 fs for coherent anti-Stokes Raman scattering microscopy," Rev. Sci. Instrum 73, 2843 DOI: (2002)
Cheng, Ji-Xin; Xie, X. Sunney "Green's function formulation for third-harmonic generation microscopy," JOSAB 19, 1604 DOI: (2002)
Potma, Eric O; Jones, David J; Cheng, Ji-Xin; Xie, X. Sunney; Ye, Jun "High-sensitivity coherent anti-Stokes Raman scattering microscopy with two tightly synchronized picosecond lasers," Optics Lett 27, 1168 DOI: (2002)
Cheng, Ji-Xin; Jia, Y. Kevin; Zheng, Gengfeng; Xie, X. Sunney "Laser-Scanning Coherent Anti-Stokes Raman Scattering Microscopy and Applications to Cell Biology," Biophys. J 83, 502 DOI: (2002)
Cheng, Ji-Xin; Volkmer, Andreas; Xie, X. Sunney "Theoretical and experimental characterization of coherent anti-Stokes Raman scattering microscopy," JOSA B 19, 1363 DOI: (2002)
Krug, John T. II; Sánchez, Erik J; Xie, X. Sunney "Design of near-field probes with optimal field enhancement by finite difference time domain electromagnetic simulation," J. Chem. Phys 116(24), 10895 DOI: (2002)
Volkmer, Andreas; Book, Lewis D; Xie, X. Sunney "Time-resolved coherent anti-Stokes Raman scattering microscopy: Imaging based on Raman free induction decay," Appl. Phys. Lett 80, 1505 DOI: (2002)
Xie, Sunney "Single-Molecule Approach to Enzymology," Single Mol. 2(4), 229-236 DOI: 10.1002/1438-5171(200112)2:4<229::aid-simo229>3.0.co;2-9 (2001)
Cheng, Ji-Xin; Book, Lewis D.; Xie, X. Sunney "Polarization coherent anti-Stokes Raman scattering microscopy," Opt. Lett. 26(17), 1341 DOI: 10.1364/ol.26.001341 (2001)
Volkmer, Andreas; Cheng, Ji-Xin; Xie, X. Sunney "Vibrational Imaging with High Sensitivity via Epidetected Coherent Anti-Stokes Raman Scattering Microscopy," Physical Review Letters 87(2) DOI: 10.1103/physrevlett.87.023901 (2001)
Cheng, Ji-xin; Volkmer, Andreas; Book, Lewis D.; Xie, X. Sunney "An Epi-Detected Coherent Anti-Stokes Raman Scattering (E-CARS) Microscope with High Spectral Resolution and High Sensitivity," J. Phys. Chem. B 105(7), 1277-1280 DOI: 10.1021/jp003774a (2001)
Schenter, Gregory K.; Lu, H. Peter; Xie, X. Sunney "Statistical Analyses and Theoretical Models of Single-Molecule Enzymatic Dynamics," J. Phys. Chem. A 103(49), 10477-10488 DOI: (1999)
Zumbusch, Andreas; Holtom, Cary R.; Xie, X. Sunney "Three-Dimensional Vibrational Imaging by Coherent Anti-Stokes Raman Scattering," Physical Review Letters 82, 4142-4145 DOI: (1999)
Xie, X. Sunney; Lu, H. Peter "Single-Molecule Enzymology," J. Biol. Chem 274, 15967 DOI: (1999)
Schenter, Greg K; Lu, H. Peter; Xie, X. Sunney "Statistical Analysis and Theoretical Models of Single-Molecule Enzymatic Dynamics," J. Phys. Chem. A 103, 10477 DOI: (1999)
Bai, Chunli; Wang, Chen; Xie, X. Sunney; Wolynes, Peter, G "Single Molecule Physics and Chemistry," Proc. Natl. Acad. Sci. USA 96, 10477 DOI: (1999)
Zumbusch, Andreas; Holtom, Gary R; Xie, X. Sunney "Vibrational Microscopy Using Coherent Anti-Stokes Raman Scattering," Phys. Rev. Lett 82, 4142 DOI: (1999)
Sánchez, Erik J; Novotny, Lukas; Xie, X. Sunney "Near-field Fluorescence Microscopy Based on Two-Photon Excitation With Metal Tips," Phys. Rev. Lett 82, 4014 DOI: (1999)
Ying, L; Xie, X. Sunney "Optical Detection of Single Molecule and its Applications," Daxue Huaxue 14, 1 DOI: (1999)
Lu, H. Peter; Xie, X. Sunney "Single-Molecule Spectroscopy Studies of Molecular Dynamics in Chemical and Biological Systems," Z. Phys. Chem. (Muenchen) 212, 59 DOI: (1999)
Lu, H. Peter; Xun, Luying; Xie, X. Sunney "Single Molecule Enzymatic Dynamics," Science 282, 1877 DOI: (1998)
Ying, Liming; Xie, X. Sunney "Fluorescence Spectroscopy, Excitation Dynamics and Photochemistry of Single Allophycocyanin Trimers," J. Phys. Chem. B 102, 10399 DOI: (1998)
Xie, X. Sunney; Trautman, Jay K "Optical studies of single molecules at room temperature," Ann. Rev. Phys. Chem 49, 441 DOI: (1998)
Novotny, Lukas; Sanchez, Erik J; Xie, X. Sunney "Near-field Optical Imaging Using Metal Tips Illuminated by Higher-order Hermite-Gaussian Beams," Ultramicroscopy 71, 21 DOI: (1998)
Sanchez, Erik J; Novotny, Lukas; Holtom, G.R; Xie, X. Sunney "Room-Temperature Fluorescence Imaging and Spectroscopy of Single Molecules by Two-Photon Excitation," J. Phys. Chem. A 101, 7019 DOI: (1997)
Novotny, Lukas; Bian, Randy X; Xie, X. Sunney "Theory of Nanometric Optical Tweezers," Phys. Rev. Lett 79, 645 DOI: (1997)
Lu, H. Peter; Xie, X. Sunney "Single-Molecule Kinetics of Interfacial Electron Transfer Temperature," J. Phys. Chem 101, 2753 DOI: (1997)
Lu, H. Peter; Xie, X. Sunney "Single-Molecule Spectral Fluctuations at Room Temperature," Nature 385, 143 DOI: (1997)
Xie, X. Sunney "Single-Molecule Spectroscopy and Dynamics at Room Temperature," Acc. Chem. Res 29, 598 DOI: (1996)
Bian, Randy X; Dunn, Robert C; Xie, X. Sunney; Leung, P. T "Single molecule emission characteristics in near-field microscopy," Phys. Rev. Lett 75, 4772 DOI: (1995)
Holtom, Gary R; Crowell, Robert A; Xie, X. Sunney "A High Repetition Rate Femtosecond Optical Parametric Oscillator-Amplifier System Near 3 Microns," J. Optic. Soc. Am. B 12, 1723 DOI: (1995)
Dunn, Robert C; Xie, X. Sunney "Characterization of the Temporal Behavior of Ultrashort Pulses Emerging from a Near-field Fiber Probe," Ultramicroscopy 57, 169 DOI: (1995)
Dunn, Robert C; Allen, Errol V; Joyce, Stephen A; Anderson, Gordon A; Xie, X. Sunney "Near-field Fluorescent Imaging of Single Proteins," Ultramicroscopy 57, 113 DOI: (1995)
Crowell, Robert A; Holtom, Gary R; Xie, X. Sunney "The Infrared Free Induction Decay of Liquid Water Molecules," J. Phys. Chem 99, 1840 DOI: (1995)
Xie, X. Sunney; Dunn, Robert C "Probing Single Molecule Dynamics," Science 265, 361 DOI: (1994)
Crowell, Robert A; Holtom, Gary R; Xie, X. Sunney "Liquid Water Dynamics Probed by Femtosecond Infrared Spectroscopy," Ultrafast Phenomena IX (Springer-Verlag) 156 DOI: (1994)
Xie, X. Sunney; Holtom, Gary R; Mets, Laurens; Dunn, Robert C "Near-field Time-Resolved Spectroscopy on Single Molecules and Photosynthetic Membranes," Ultrafast Phenomena IX (Springer-Verlag) 124 DOI: (1994)
Dunn, Robert C; Holtom, Gary R; Mets, Laurens; Xie, X. Sunney "Near-Field Fluorescence Imaging and Florescence Lifetime Measurements of Light Harvesting Complexes in Intact Photosynthetic Membranes," J. Phys. Chem 98, 3094 DOI: (1994)