Celebrating the 70th anniversary of the discovery of DNA's double helix structure

Children's Chorus - “You Raise Me Up”

CPL Documentary

Welcome Remarks by Sunney Xie, CPL Director

Special Remarks by James Watson

Documentary - Discovery of DNA Double Helix

Shankar Balasubramanian：

Cambridge DNA

Tom Maniatis：

Harvard, the Cold Spring Harbor Lab and Caltech

Maoyen Chi：

China's Life Science after DNA Double Helix

Panel Discussion (Sunney Xie, Tom Maniatis, Shankar Balasubramanian, Maoyen Chi)

Shankar Balasubramanian:

DNA: What is it Telling us?

Hagan Bayley:

Nanopores: DNA Sequencing and Beyond

Yanyi Huang:

Fluorogenic DNA Sequencing

Feng Zhang:

Exploration of Biological Diversity to Improve Human Health

Wensheng Wei:

Gene Editing and Beyond

Sunney Xie:

The Central Dogma Choreography: Regulation of Gene Modules via Transcription Factor Combinations

Yanhui Xu:

Structural Insights into Transcription Initiation

Hisao Masai:

Transcription can Drive FDNA Replication

Xiangdong Fu:

RNA: Beyond a Message from DNA to Protein

Fred Alt:

The Fundamental Mechanistic Roles of Chromatin Loop Extrusion in Antibody Gene Diversification

Tak Wah Mak:

Neuro-immune Modulations in Health and Diseases

Zhijian “James” Chen:

The Dark Side of DNA - How the Immune System Senses DNA as a Danger Signal

Feng Shao:

Pyroptosis: From Antibacterial Immunity to Antitumor Immunity

Robert Langer:

From Nanotechnology to mRNA Vaccines

Live Sand Painting Performance of DNA Double Helix 70

Guest Reflections (Tom Maniatis, Feng Shao, Shankar Balasubramanian, Fred Alt, Dennis Lo, James Chen, Don Cleveland, Sunney Xie)

Anjana Rao:

Mutations in Clonal Hematopoiesis Compromise Heterochromatin Integrity

Yi Zhang:

5mC Oxidation and Beyond

Guoliang Xu:

Biological Modifications of DNA Cytosine Base

Yiqin Gao:

Relating Cell State Dependent Methylation to the DNA Sequence and 3D Genome

Fuchou Tang:

Single Cell Omics Sequencing Technologies: The Third Generation

William Greenleaf:

Exploring the Physical Genome

Bing Ren:

Unlocking the Genome's Regulatory Code

Long Cai:

Spatial Genomics

Xiaodong Wang:

Dissecting Biochemical Pathways of Regulated Cell Death

Dennis Lo：

Creating a Paradigm Shift in Prenatal Diagnostics using Circulating DNA

Jie Qiao：

Searching for Keys from the Genome: Thirty Years of PGT

Zemin Zhang：

Tumor Heterogeneity at the Microenvironment Level and its Implication in Personalized Immunotherapy

Yunlong Cao：

Broad-spectrum SARS-CoV-2 Therapeutics and Prophylactics designed based on Viral Evolution Prediction

Tom Maniatis：

The Protocadherin Gene Cluster: A Bar Code Generator for Single Neuron Self-Recognition in the Mammalian Brain

Don Cleveland：

Designer DNA Drug Therapy for Neurodegenerative Disease

Joseph Ecker：

What Lies Above? Mapping the Human Brain Epigenome

Xiaoqun Wang：

Human Brain Genomics: A Journey through Development, Evolution and Disease

Hesheng Liu：

Advances in Functional Brain Imaging Technology

Sunney Xie：