Publications

Cao, Yunlong; Wang, Jing; Jian, Fanchong; Xiao, Tianhe; Song, Weiliang; Yasimayi, Ayijiang; Huang, Weijin; Li, Qianqian; Wang, Peng; An, Ran; Wang, Jing; Wang, Yao; Niu, Xiao; Yang, Sijie; Liang, Hui; Sun, Haiyan; Li, Tao; Yu, Yuanling; Cui, Qianqian; Liu, Shuo; Yang, Xiaodong; Du, Shuo; Zhang, Zhiying; Hao, Xiaohua; Shao, Fei; Jin, Ronghua; Wang, Xiangxi; Xiao, Junyu; Wang, Youchun; Xie, Xiaoliang Sunney "Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies," Nature 602, 657-663 DOI: 10.1038/s41586-021-04385-3 (2021)
Du, Shuo; Liu, Pulan; Zhang, Zhiying; Xiao, Tianhe; Yasimayi, Ayijiang; Huang, Weijin; Wang, Youchun; Cao, Yunlong; Xie, Xiaoliang Sunney; Xiao, Junyu "Structures of SARS-CoV-2 B.1.351 neutralizing antibodies provide insights into cocktail design against concerning variants," Cell Research 31, 1130–1133 DOI: 10.1038/s41422-021-00555-0 (2021)
Cao, Yunlong; Yisimayi, Ayijiang; Bai, Yali; Huang, Weijin; Li, Xiaofeng; Zhang, Zhiying; Yuan, Tianjiao; An, Ran; Wang, Jing; Xiao, Tianhe; Du, Shuo; Ma, Wenping; Song, Liyang; Li, Yongzheng; Li, Xiang; Song, Weiliang; Wu, Jiajing; Liu, Shuo; Li, Xuemei; Zhang, Yonghong; Su, Bin; Guo, Xianghua; Wei, Yangyang; Gao, Chuanping; Zhang, Nana; Zhang, Yifei; Dou, Yang; Xu, Xiaoyu; Shi, Rui; Lu, Bai; Jin, Ronghua; Ma, Yingmin; Qin, Chengfeng; Wang, Youchun; Feng, Yingmei; Xiao, Junyu; Xie, Xiaoliang Sunney "Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines," Cell Research 31(7), 732-741 DOI: 10.1038/s41422-021-00514-9 (2021)
Xing, Dong; Tan, Longzhi; Chang, Chi-Han; Li, Heng; Xie, X. Sunney "Accurate SNV detection in single cells by transposon-based whole-genome amplification of complementary strands," PNAS 118(8), e2013106118 DOI: 10.1073/pnas.2013106118 (2021)
Tan, Longzhi; Ma, Wenping; Wu, Honggui; Sun, Wenjie; Zheng, Yinghui; Xing, Dong; Chen, Ritchie; Li, Xiang; Daley, Nicholas; Deisseroth, Karl; Xie, X. Sunney "Changes in genome architecture and transcriptional dynamics progress independently of sensory experience during post-natal brain development," Cell 184(3), 741-758 DOI: 10.1016/j.cell.2020.12.032 (2021)
Du, Shuo; Cao, Yunlong; Zhu, Qinyu; YU, Pin; Qi, Feifei; Wang, Guopeng; Du, Xiaoxia; Bao, Linlin; Deng, Wei; Zhu, Hua; Liu, Jiangning; Nie, Jianhui; Zheng, Yinghui; Liang, Haoyu; Liu, Ruixue; Gong, Shuran; Liu, Jiangning; Xu, Hua; Yisimayi, Ayijiang; Lv, Qi; Wang, Bo; He, Runsheng; Han, Yunlin; Zhao, Wenjie; Bai, Yali; Qu, Yajin; Gao, Xiang; Ji, Chenggong; Wang, Qisheng; Gao, Ning; Huang, Weijin; Wang, Youchun; Xie, X. Sunney; Su, Xiao-dong; Xiao, Junyu; Qin, Chuan "Structurally resolved SARS-CoV-2 antibody shows high efficacy in severely infected hamsters and provides a potent cocktail pairing strategy," Cell 183(4), 1013-1023.e13 DOI: 10.1016/j.cell.2020.09.035 (2020)
Su, Qian Peter; Zhao, Ziqing Winston; Meng, Luming; Ding, Miao; Zhang, Weiwei; Li, Yongzheng; Liu, Mengzhu; Li, Rongqin; Gao, Yi-Qin; Xie, X. Sunney; Sun, Yujie "Superresolution imaging reveals spatiotemporal propagation of human replication foci mediated by CTCF-organized chromatin structures," PNAS 117(26), 15036-15046 DOI: 10.1073/pnas.2001521117 (2020)
Cao, Yunlong; Su, Bin; Guo, Xianghua; Sun, Wenjie; Deng, Yongqiang; Bao, Linlin; Zhu, Qinyu; Zhang, Xu; Zheng, Yinghui; Geng, Chenyang; Chai, Xiaoran; He, Runsheng; Li, Xiaofeng; Lv, Qi; Zhu, Hua; Deng, Wei; Xu, Yanfeng; Wang, Yanjun; Qiao, Luxin; Tan, Yafang; Song, Liyang; Wang, Guopeng; Du, Xiaoxia; Gao, Ning; Liu, Jiangning; Xiao, Junyu; Su, Xiaodong; Du, Zongmin; Feng, Yingmei; Qin, Chuan; Qin, Chengfeng; Jin, Ronghua; Xie, X. Sunney "Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients' B Cells," Cell 182(1), 73-84.e16 DOI: 10.1016/j.cell.2020.05.025 (2020)
Di, Lin; Fu, Yusi; Sun, Yue; Li, Jie; Lu, Liu; Yao, Jiacheng; Wang, Guanbo; Wu, Yalei; Lao, kaiqin; Ding, Miao; Lee, Raymond W.; Zheng, Genhua; Xu, Jun; Oh, Juntaek; Wang, Dong; Xie, X. Sunney; Huang, Yanyi; Wang, Jianbin "RNA sequencing by direct tagmentation of RNA/DNA hybrids," PNAS 117(6), 2886-2893 DOI: 10.1073/pnas.1919800117 (2020)
Xie, X. Sunney "Diseases Have No Borders, Neither Should Research!," Cell 178(6) DOI: 10.1016/j.cell.2019.07.053 (2019)
Huang, Lei; Bogale, Berhan; Tang, Yaqiong; Lu, Sijia; Xie, X.Sunney; Racowsky, Catherine "Noninvasive preimplantation genetic testing for aneuploidy in spent medium may be more reliable than trophectoderm biopsy," PNAS 16(208), 14105-14112 DOI: 10.1073/pnas.1907472116 (2019)
Tan, Longzhi; Xing, Dong; Daley, Nicholas; Xie, X.Sunney "Three-dimensional genome structures of single sensory neurons in mouse visual and olfactory systems," Nat Struct Mol Biol 26, 297-307 DOI: 10.1038/s41594-019-0205-2 (2019)
Xiong, Luoxing; Huang, Lei; Tian, Feng; Lu, Sijia; Xie, X.Sunney "Bayesian model for accurate MARSALA (mutated allele revealed by sequencing with aneuploidy and linkage analyses)," J Assist Reprod Genet 36(6), 1263-1271 DOI: 10.1007/s10815-019-01451-8 (2019)
Ji, Minbiao; Arbel, Michal; Zhang, Lili; Freudiger, Christian W.; Hou, Steven S.; Lin, Dongdong; Yang, Xinju; Bacskai, Brian J.; Xie, X.Sunney "Label-free imaging of amyloid plaques in Alzheimer’s disease with stimulated Raman scattering microscopy," Sci Adv 4(11), eaat7715 DOI: 10.1126/sciadv.aat7715 (2018)
Tan, Longzhi; Xing, Dong; Chang, Chi-Han; Li, Heng; Xie, X.Sunney "Three-dimensional genome structures of single diploid human cells," Science 43, 924-928 DOI: 10.1126/science.aat5641 (2018)
Wu, Haitao; Shen, Xiaoting; Huang, Lei; Zeng, Yanhong; Gao, Yumei; Shao, Lin; Lu, Baomin; Zhong, Yiping; Miao, Benyu; Xu, Yanwen; Wang, Yali; Li, Yubin; Li, Yubin; Xiong, Luoxing; Lu, Sijia; Xie, X.Sunney; Zhou, Canquan "Genotyping single-sperm cells by universal MARSALA enables the acquisition of linkage information for combined pre-implantation genetic diagnosis and genome screening," J Assist Reprod Genet 35(6), 1071-1078 DOI: 10.1007/s10815-018-1158-9 (2018)
Blanshard, Robert C; Chen, Chongyi; Xie, X.Sunney; Hoffmann, Eva R "Single cell genomics to study DNA and chromosome changes in human gametes and embryos," Methods in Cell Biology 144, 441-457 DOI: 10.1016/bs.mcb.2018.03.037 (2018)
Tan, Longzhi; Xie, X.Sunney "A Near-complete Spatial Map of Olfactory Receptors in the Mouse Main Olfactory Epithelium," Chem Senses 43(6), 427-432 DOI: 10.1093/chemse/bjy030 (2018)
Chen, Zitian; Zhou, Wenxiong; Qiao, Shuo; Kang, Li; Duan, Haifeng; Xie, X Sunney; Huang, Yanyi "Highly accurate fluorogenic DNA sequencing with information theory–based error correction," Nat Biotechnol 35(12), 1170-1178 DOI: 10.1038/nbt.3982 (2017)
Gao, Yan; Ni, Xiaohui; Guo, Hua; Su, Zhe; Ba, Yi; Tong, Zhongsheng; Guo, Zhi; Yao, Xin; Chen, Xixi; Yin, Jian; Yan, Zao; Liu, Ying; Bai, Fan; Xie, X. Sunney; Zhang, Ning "Single-cell sequencing deciphers a convergent evolution of copy number alterations from primary to circulating tumor cells," Genome Research 27, 1312-1322 DOI: 10.1101/gr.216788.116 (2017)
Chen, Chongyi; Xing, Dong; Tan, Longzhi; Li, Heng; Zhou, Guangyu; Huang, Lei; Xie, Xiaoliang S. "Single-cell whole-genome analyses by Linear Amplification via Transposon Insertion (LIANTI)," Science 356, 189-194 DOI: 10.1126/science.aak9787 (2017)
Zhou, Yuexin; Wang, Ping; Tian, Feng; Gao, Ge; Huang, Lei; Wei, Wensheng; Xie, Xiaoliang S. "Painting a specific chromosome with CRISPR/Cas9 for live-cell imaging," Cell Res 356 DOI: 10.1038/cr.2017.9 (2017)
Fu, Dan; Yang, Wenlong; Xie, Xiaoliang S. "Label-free Imaging of Neurotransmitter Acetylcholine at Neuromuscular Junctions with Stimulated Raman Scattering," J Am Chem Soc 139(2), 583−586 DOI: 10.1021/jacs.6b10727 (2017)
Yang, Wenlong; Li, Ang; Suo, Yuanzhen; Lu, Fa-Ke; Xie, Xiaoliang S. "Simultaneous two-color stimulated Raman scattering microscopy by adding a fiber amplifier to a 2 ps OPO-based SRS microscope," Opt Lett 42(3), 523-526 DOI: 10.1364/OL.42.000523 (2017)
Xu, Jiawei; Zhang, Zhen; Niu, Wenbin; Yang, Qingling; Yao, Guidong; Shi, Senlin; Jin, Haixia; Song, Qingling; Yang, Wenyan; Yang, Qingling; Chen, Lei; Zhang, Xiangyang; Guo, Yihong; Su, Yingchun; Chen, Lei; Hu, Linli; Zhai, Jun; Chen, Lei; Zhang, Yile; Dong, Fangli; Gao, Yumei; Chen, Lei; Li, Wenhui; Bo, Shiping; Hu, Mintao; Ren, Jun; Huang, Lei; Lu, Sijia; Xie, Xiaoliang S.; Sun, Yingpu "Mapping allele with resolved carrier status of Robertsonian and reciprocal translocation in human preimplantation embryos," Proc Natl Acad Sci USA 114(41), E8695-E8702 DOI: 10.1073/pnas.1715053114 (2017)
Lee, David F.; Lu, Jenny; Chang, Seungwoo; Loparo, Joseph J.; Xie, Xiaoliang S. "Mapping DNA polymerase errors by single-molecule sequencing," Nucleic Acids Research , gkw436 DOI: 10.1093/nar/gkw436 (2016)
Zhao, Ziqing W; Xie, X.Sunney; Ge, Hao "Nonequilibrium Relaxation of Conformational Dynamics Facilitates Catalytic Reaction in an Elastic Network Model of T7 DNA Polymerase," J Phys Chem B120(11), 2869-2877 DOI: 10.1021/acs.jpcb.5b11002 (2016)
Pu, Yingying; Zhao, Zhilun; Li, Yingxing; Zou, Jin; Ma, Qi; Zhao, Yanna; Ke, Yuehua; Chen, Huiyi; Baker, Matthew A.B.; Sun, Yujie; Xie, X.Sunney; Bai, Fan "Enhanced Efflux Activity Facilitates Drug Tolerance in Dormant Bacterial Cells," Molecular compelling 62, 284-294 DOI: 10.1016/j.molcel.2016.03.035 (2016)
Lu, Fa-Ke; Calligaris, David; Olubiyi, Olutayo I.; Norton, Isaiah; Yang, Wen Long; Santagata, Sandro; Xie, X.Sunney; Golby, Alexandra J.; Agar, Nathalie Y. R. "Label-Free Neurosurgical Pathology with Stimulated Raman Imaging," Cancer Res 76, 3451-3462 DOI: 10.1158/0008-5472.CAN-16-027 (2016)
Xu, Juanjuan; Fang, Rui; Chen, Li; Chen, Daozhen; Xiao, Jian-Ping; Yang, Weimin; Wang, Honghua; Song, Xiaoqing; Ma, Ting; Bo, Shiping; Shi, Chong; Ren, Jun; Huang, Lei; Cai, Li-Yi; Yao, Bing; Xie, X.Sunney; Lu, Sijia "Noninvasive chromosome screening of human embryos by genome sequencing of embryo culture medium for in vitro fertilization," Proc Natl Acad Sci USA 113(42), 11907-11912 DOI: 10.1073/pnas.1613294113 (2016)
Tian, Feng; Yang, Wenlong; Mordes, Daniel A; Wang, Jin-Yuan; Salameh, Johnny S; Mok, Joanie; Chew, Jeannie; Sharma, Aarti; Leno-Duran, Ester; Suzuki-Uematsu, Satomi; Suzuki, Naoki; Han, Steve S; Lu, Fa-Ke; Ji, Minbiao; Zhang, Rosanna; Liu, Yue; Strominger, Jack; Shneider, Neil A; Petrucelli, Leonard; Xie, X. Sunney; Eggan, Kevin "Monitoring peripheral nerve degeneration in ALS by label-free stimulated Raman scattering imaging," Nat Commun 7, 13283 DOI: 10.1038/ncomms13283 (2016)
Chen, H.; Shiroguchi, K.; Ge, H.; Xie, X. S. "Genome-wide study of mRNA degradation and transcript elongation in Escherichia coli," Molecular Systems Biology 11(1), 781-781 DOI: 10.15252/msb.20145794 (2015)
Ge, Hao; Qian, Hong; Xie, X. Sunney "Stochastic Phenotype Transition of a Single Cell in an Intermediate Region of Gene State Switching," Physical Review Letters 114(7) DOI: 10.1103/PhysRevLett.114.078101 (2015)
Chapman, Alec R.; He, Zi; Lu, Sijia; Yong, Jun; Tan, Longzhi; Tang, Fuchou; Xie, X. Sunney "Single Cell Transcriptome Amplification with MALBAC," PLoS ONE 10(3), e0120889 DOI: 10.1371/journal.pone.0120889 (2015)
Xie, Xiaoliang Sunney "Single Molecules Meet Genomics: Pinpointing Precision Medicine," JAMA 313(20), 2021 DOI: 10.1001/jama.2015.5533 (2015)
Huang, Lei; Ma, Fei; Chapman, Alec; Lu, Sijia; Xie, Xiaoliang Sunney "Single-Cell Whole-Genome Amplification and Sequencing: Methodology and Applications," Annu. Rev. Genom. Human Genet. 16(1), 79-102 DOI: 10.1146/annurev-genom-090413-025352 (2015)
Lu, Fa-Ke; Basu, Srinjan; Igras, Vivien; Hoang, Mai P.; Ji, Minbiao; Fu, Dan; Holtom, Gary R.; Neel, Victor A.; Freudiger, Christian W.; Fisher, David E.; Xie, X. Sunney "Label-free DNA imaging in vivo with stimulated Raman scattering microscopy," Proc Natl Acad Sci USA 112(37), 11624-11629 DOI: 10.1073/pnas.1515121112 (2015)
Fu, Yusi; Li, Chunmei; Lu, Sijia; Zhou, Wenxiong; Tang, Fuchou; Xie, X. Sunney; Huang, Yanyi "Uniform and accurate single-cell sequencing based on emulsion whole-genome amplification," Proc Natl Acad Sci USA 112(38), 11923-11928 DOI: 10.1073/pnas.1513988112 (2015)
Ji, M.; Lewis, S.; Camelo-Piragua, S.; Ramkissoon, S. H.; Snuderl, M.; Venneti, S.; Fisher-Hubbard, A.; Garrard, M.; Fu, D.; Wang, A. C.; Heth, J. A.; Maher, C. O.; Sanai, N.; Johnson, T. D.; Freudiger, C. W.; Sagher, O.; Xie, X. S.; Orringer, D. A. "Detection of human brain tumor infiltration with quantitative stimulated Raman scattering microscopy," Science Translational Medicine 7(309), 309ra163-309ra163 DOI: 10.1126/scitranslmed.aab0195 (2015)
Cheng, J.-X.; Xie, X. S. "Vibrational spectroscopic imaging of living systems: An emerging platform for biology and medicine," Science 350(6264), aaa8870-aaa8870 DOI: 10.1126/science.aaa8870 (2015)
Tan, L.; Li, Q.; Xie, X. S. "Olfactory sensory neurons transiently express multiple olfactory receptors during development," Molecular Systems Biology 11(12), 844-844 DOI: 10.15252/msb.20156639 (2015)
Yan, Liying; Huang, Lei; Xu, Liya; Huang, Jin; Ma, Fei; Zhu, Xiaohui; Tang, Yaqiong; Liu, Mingshan; Lian, Ying; Liu, Ping; Li, Rong; Lu, Sijia; Tang, Fuchou; Qiao, Jie; Xie, X. Sunney "Live births after simultaneous avoidance of monogenic diseases and chromosome abnormality by next-generation sequencing with linkage analyses," Proc Natl Acad Sci USA 112(52), 15964-15969 DOI: 10.1073/pnas.1523297113 (2015)
Gu, Chan; Zhang, Jun; Yang, Y. Isaac; Chen, Xi; Ge, Hao; Sun, Yujie; Su, Xiaodong; Yang, Lijiang; Xie, Sunney; Gao, Yi Qin "DNA Structural Correlation in Short and Long Ranges," J. Phys. Chem. B 119(44), 13980-13990 DOI: 10.1021/acs.jpcb.5b06217 (2015)
Chong, Shasha; Chen, Chongyi; Ge, Hao; Xie, X. Sunney "Mechanism of Transcriptional Bursting in Bacteria," Cell 158(2), 314-326 DOI: 10.1016/j.cell.2014.05.038 (2014)
Fu, Dan; Xie, X. Sunney "Reliable Cell Segmentation Based on Spectral Phasor Analysis of Hyperspectral Stimulated Raman Scattering Imaging Data," Anal. Chem. 86(9), 4115-4119 DOI: 10.1021/ac500014b (2014)
Fu, Dan; Yu, Yong; Folick, Andrew; Currie, Erin; Farese, Robert V.; Tsai, Tsung-Huang; Xie, Xiaoliang Sunney; Wang, Meng C. " In Vivo Metabolic Fingerprinting of Neutral Lipids with Hyperspectral Stimulated Raman Scattering Microscopy ," Journal of the American Chemical Society 136(24), 8820-8828 DOI: 10.1021/ja504199s (2014)
Fu, Dan; Zhou, Jing; Zhu, Wenjing Suzanne; Manley, Paul W.; Wang, Y. Karen; Hood, Tami; Wylie, Andrew; Xie, X. Sunney "Imaging the intracellular distribution of tyrosine kinase inhibitors in living cells with quantitative hyperspectral stimulated Raman scattering," Nature Chem 6(7), 614-622 DOI: 10.1038/nchem.1961 (2014)
Freudiger, Christian W.; Yang, Wenlong; Holtom, Gary R.; Peyghambarian, Nasser; Xie, X. Sunney; Kieu, Khanh Q. "Stimulated Raman scattering microscopy with a robust fibre laser source," Nature Photon 8(2), 153-159 DOI: 10.1038/nphoton.2013.360 (2014)
Zhao, Z. W.; Roy, R.; Gebhardt, J. C. M.; Suter, D. M.; Chapman, A. R.; Xie, X. S. "Spatial organization of RNA polymerase II inside a mammalian cell nucleus revealed by reflected light-sheet superresolution microscopy," Proceedings of the National Academy of Sciences 111(2), 681-686 DOI: 10.1073/pnas.1318496111 (2014)
Xie, X. S. "Enzyme Kinetics, Past and Present," Science 342(6165), 1457-1459 DOI: 10.1126/science.1248859 (2013)
Hou, Yu; Fan, Wei; Yan, Liying; Li, Rong; Lian, Ying; Huang, Jin; Li, Jinsen; Xu, Liya; Tang, Fuchou; Xie, X. Sunney; Qiao, Jie "Genome Analyses of Single Human Oocytes," Cell 155(7), 1492-1506 DOI: 10.1016/j.cell.2013.11.040 (2013)
Tan, L.; Zong, C.; Xie, X. S. "Rare event of histone demethylation can initiate singular gene expression of olfactory receptors," Proceedings of the National Academy of Sciences 110(52), 21148-21152 DOI: 10.1073/pnas.1321511111 (2013)
Ni, X.; Zhuo, M.; Su, Z.; Duan, J.; Gao, Y.; Wang, Z.; Zong, C.; Bai, H.; Chapman, A. R.; Zhao, J.; Xu, L.; An, T.; Ma, Q.; Wang, Y.; Wu, M.; Sun, Y.; Wang, S.; Li, Z.; Yang, X.; Yong, J.; Su, X.-D.; Lu, Y.; Bai, F.; Xie, X. S.; Wang, J. "Reproducible copy number variation patterns among single circulating tumor cells of lung cancer patients," Proceedings of the National Academy of Sciences 110(52), 21083-21088 DOI: 10.1073/pnas.1320659110 (2013)
Ji, M.; Orringer, D. A.; Freudiger, C. W.; Ramkissoon, S.; Liu, X.; Lau, D.; Golby, A. J.; Norton, I.; Hayashi, M.; Agar, N. Y. R.; Young, G. S.; Spino, C.; Santagata, S.; Camelo-Piragua, S.; Ligon, K. L.; Sagher, O.; Xie, X. S. "Rapid, Label-Free Detection of Brain Tumors with Stimulated Raman Scattering Microscopy," Science Translational Medicine 5(201), 201ra119-201ra119 DOI: 10.1126/scitranslmed.3005954 (2013)
Xu, Xinliang; Ge, Hao; Gu, Chan; Gao, Yi Qin; Wang, Siyuan S.; Thio, Beng Joo Reginald; Hynes, James T.; Xie, X. Sunney; Cao, Jianshu "Modeling Spatial Correlation of DNA Deformation: DNA Allostery in Protein Binding," J. Phys. Chem. B 117(42), 13378-13387 DOI: 10.1021/jp4047243 (2013)
Gebhardt, J Christof M; Suter, David M; Roy, Rahul; Zhao, Ziqing W; Chapman, Alec R; Basu, Srinjan; Maniatis, Tom; Xie, X Sunney "Single-molecule imaging of transcription factor binding to DNA in live mammalian cells," Nat Meth 10(5), 421-426 DOI: 10.1038/nmeth.2411 (2013)
Fu, Dan; Holtom, Gary; Freudiger, Christian; Zhang, Xu; Xie, Xiaoliang Sunney "Hyperspectral Imaging with Stimulated Raman Scattering by Chirped Femtosecond Lasers," J. Phys. Chem. B 117(16), 4634-4640 DOI: 10.1021/jp308938t (2013)
Kim, S.; Brostromer, E.; Xing, D.; Jin, J.; Chong, S.; Ge, H.; Wang, S.; Gu, C.; Yang, L.; Gao, Y. Q.; Su, X.-d.; Sun, Y.; Xie, X. S. "Probing Allostery Through DNA," Science 339(6121), 816-819 DOI: 10.1126/science.1229223 (2013)
Kong, Lingjie; Ji, Minbiao; Holtom, Gary R.; Fu, Dan; Freudiger, Christian W.; Xie, X. Sunney "Multicolor stimulated Raman scattering microscopy with a rapidly tunable optical parametric oscillator," Opt. Lett. 38(2), 145 DOI: 10.1364/ol.38.000145 (2013)
Zong, C.; Lu, S.; Chapman, A. R.; Xie, X. S. "Genome-Wide Detection of Single-Nucleotide and Copy-Number Variations of a Single Human Cell," Science 338(6114), 1622-1626 DOI: 10.1126/science.1229164 (2012)
Lu, S.; Zong, C.; Fan, W.; Yang, M.; Li, J.; Chapman, A. R.; Zhu, P.; Hu, X.; Xu, L.; Yan, L.; Bai, F.; Qiao, J.; Tang, F.; Li, R.; Xie, X. S. "Probing Meiotic Recombination and Aneuploidy of Single Sperm Cells by Whole-Genome Sequencing," Science 338(6114), 1627-1630 DOI: 10.1126/science.1229112 (2012)
Freudiger, Christian W; Pfannl, Rolf; Orringer, Daniel A; Saar, Brian G; Ji, Minbiao; Zeng, Qing; Ottoboni, Linda; Ying, Wei; Waeber, Christian; Sims, John R; De Jager, Philip L; Sagher, Oren; Philbert, Martin A; Xu, Xiaoyin; Kesari, Santosh; Xie, X Sunney; Young, Geoffrey S "Multicolored stain-free histopathology with coherent Raman imaging," Laboratory Investigation 92(10), 1492-1502 DOI: 10.1038/labinvest.2012.109 (2012)
Lu, Fa-Ke; Ji, Minbiao; Fu, Dan; Ni, Xiaohui; Freudiger, Christian W.; Holtom, Gary; Xie, X. Sunney "Multicolor stimulated Raman scattering microscopy," Molecular Physics 110(15-16), 1927-1932 DOI: 10.1080/00268976.2012.695028 (2012)
Lefrancois, Simon; Fu, Dan; Holtom, Gary R.; Kong, Lingjie; Wadsworth, William J.; Schneider, Patrick; Herda, Robert; Zach, Armin; Sunney Xie, X.; Wise, Frank W. "Fiber four-wave mixing source for coherent anti-Stokes Raman scattering microscopy," Opt. Lett. 37(10), 1652 DOI: 10.1364/ol.37.001652 (2012)
Zhang, Xu; Roeffaers, Maarten B. J.; Basu, Srinjan; Daniele, Joseph R.; Fu, Dan; Freudiger, Christian W.; Holtom, Gary R.; Xie, X. Sunney "Label-Free Live-Cell Imaging of Nucleic Acids Using Stimulated Raman Scattering Microscopy," ChemPhysChem 13(4), 1054-1059 DOI: 10.1002/cphc.201100890 (2012)
Fu, Dan; Lu, Fa-Ke; Zhang, Xu; Freudiger, Christian; Pernik, Douglas R.; Holtom, Gary; Xie, Xiaoliang Sunney "Quantitative Chemical Imaging with Multiplex Stimulated Raman Scattering Microscopy," Journal of the American Chemical Society 134(8), 3623-3626 DOI: 10.1021/ja210081h (2012)
Shiroguchi, K.; Jia, T. Z.; Sims, P. A.; Xie, X. S. "Digital RNA sequencing minimizes sequence-dependent bias and amplification noise with optimized single-molecule barcodes," Proceedings of the National Academy of Sciences 109(4), 1347-1352 DOI: 10.1073/pnas.1118018109 (2012)
Wang, W.; Li, G.-W.; Chen, C.; Xie, X. S.; Zhuang, X. "Chromosome Organization by a Nucleoid-Associated Protein in Live Bacteria," Science 333(6048), 1445-1449 DOI: 10.1126/science.1204697 (2011)
Li, Gene-Wei; Xie, X. Sunney "Central dogma at the single-molecule level in living cells," Nature 475(7356), 308-315 DOI: 10.1038/nature10315 (2011)
Saar, Brian G.; Johnston, Richard S.; Freudiger, Christian W.; Xie, X. Sunney; Seibel, Eric J. "Coherent Raman scanning fiber endoscopy," Opt. Lett. 36(13), 2396 DOI: 10.1364/ol.36.002396 (2011)
Sims, Peter A; Greenleaf, William J; Duan, Haifeng; Xie, X Sunney "Fluorogenic DNA sequencing in PDMS microreactors," Nat Meth 8(7), 575-580 DOI: 10.1038/nmeth.1629 (2011)
Saar, Brian G.; Contreras-Rojas, L. Rodrigo; Xie, X. Sunney; Guy, Richard H. "Imaging Drug Delivery to Skin with Stimulated Raman Scattering Microscopy," Molecular Pharmaceutics 8(3), 969-975 DOI: 10.1021/mp200122w (2011)
Freudiger, Christian W.; Roeffaers, Maarten B. J.; Zhang, Xu; Saar, Brian G.; Min, Wei; Xie, X. Sunney "Optical Heterodyne-Detected Raman-Induced Kerr Effect (OHD-RIKE) Microscopy," J. Phys. Chem. B 115(18), 5574-5581 DOI: 10.1021/jp1113834 (2011)
Min, Wei; Freudiger, Christian W.; Lu, Sijia; Xie, X. Sunney "Coherent Nonlinear Optical Imaging: Beyond Fluorescence Microscopy," Annu. Rev. Phys. Chem. 62(1), 507-530 DOI: 10.1146/annurev.physchem.012809.103512 (2011)
Roeffaers, Maarten B. J.; Zhang, Xu; Freudiger, Christian W.; Saar, Brian G.; Ruijven, Marjolein van; Dalen, Gerard van; Xiao, Chunhong; Xie, X. Sunney "Label-free imaging of biomolecules in food products using stimulated Raman microscopy," Journal of Biomedical Optics 16(2), 021118 DOI: 10.1117/1.3516591 (2011)
Freudiger, Christian W.; Min, Wei; Holtom, Gary R.; Xu, Bingwei; Dantus, Marcos; Sunney Xie, X. "Highly specific label-free molecular imaging with spectrally tailored excitation-stimulated Raman scattering (STE-SRS) microscopy," Nature Photon 5(2), 103-109 DOI: 10.1038/nphoton.2010.294 (2011)
Wang, Meng C; Min, Wei; Freudiger, Christian W; Ruvkun, Gary; Xie, X Sunney "RNAi screening for fat regulatory genes with SRS microscopy," Nat Meth 8(2), 135-138 DOI: 10.1038/nmeth.1556 (2011)
Taniguchi, Yuichi; Choi, Paul J.; Li, Gene-Wei; Chen, Huiyi; Babu, Mohan; Hearn, Jeremy; Emili, Andrew; Xie, X. Sunney "Quantifying E. coli Proteome and Transcriptome with Single-Molecule Sensitivity in Single Cells," Science 329(5991), 533-538 DOI: 10.1126/science.1188308 (2010)
Saar, B. G.; Freudiger, C. W.; Reichman, J.; Stanley, C. M.; Holtom, G. R.; Xie, X. S. "Video-Rate Molecular Imaging in Vivo with Stimulated Raman Scattering," Science 330(6009), 1368-1370 DOI: 10.1126/science.1197236 (2010)
Chong, Shasha; Min, Wei; Xie, X. Sunney "Ground-State Depletion Microscopy: Detection Sensitivity of Single-Molecule Optical Absorption at Room Temperature," The Journal of Physical Chemistry Letters 1(23), 3316-3322 DOI: 10.1021/jz1014289 (2010)
Wang, Ke; Freudiger, Christian W.; Lee, Jennifer H.; Saar, Brian G.; Xie, X. Sunney; Xu, Chris "Synchronized time-lens source for coherent Raman scattering microscopy," Optics Express 18(23), 24019 DOI: 10.1364/oe.18.024019 (2010)
Xie, X. S. "Single Molecule Spectroscopy in Chemistry, Physics and Biology," Springer Series in Chemical Physics DOI: 10.1007/978-3-642-02597-6 (2010)
Choi, Paul J.; Xie, X. Sunney; Shakhnovich, Eugene I. "Stochastic Switching in Gene Networks Can Occur by a Single-Molecule Event or Many Molecular Steps," Journal of Molecular Biology 396(1), 230-244 DOI: 10.1016/j.jmb.2009.11.035 (2009)
Saar, Brian G.; Zeng, Yining; Freudiger, Christian W.; Liu, Yu-San; Himmel, Michael E.; Xie, X. Sunney; Ding, Shi-You "Label-Free, Real-Time Monitoring of Biomass Processing with Stimulated Raman Scattering Microscopy," Angewandte Chemie International Edition 49(32), 5476-5479 DOI: 10.1002/anie.201000900 (2010)
Min, Wei; Jiang, Liang; Xie, X. Sunney "Complex Kinetics of Fluctuating Enzymes: Phase Diagram Characterization of a Minimal Kinetic Scheme," Chemistry - An Asian Journal 5(5), 1129-1138 DOI: 10.1002/asia.200900627 (2010)
Lu, Sijia; Min, Wei; Chong, Shasha; Holtom, Gary R.; Xie, X. Sunney "Label-free imaging of heme proteins with two-photon excited photothermal lens microscopy," Applied Physics Letters 96(11), 113701 DOI: 10.1063/1.3308485 (2010)
Zeng, Yining; Saar, Brian G.; Friedrich, Marcel G.; Chen, Fang; Liu, Yu-San; Dixon, Richard A.; Himmel, Michael E.; Xie, X. Sunney; Ding, Shi-You "Imaging Lignin-Downregulated Alfalfa Using Coherent Anti-Stokes Raman Scattering Microscopy," Bioenerg. Res. 3(3), 272-277 DOI: 10.1007/s12155-010-9079-1 (2010)
Kim, Sangjin; Schroeder, Charles M.; Xie, X. Sunney "Single-Molecule Study of DNA Polymerization Activity of HIV-1 Reverse Transcriptase on DNA Templates," Journal of Molecular Biology 395(5), 995-1006 DOI: 10.1016/j.jmb.2009.11.072 (2010)
Freudiger, Christian W.; Min, Wei; Saar, Brian G.; Xie, X. Sunney "Stimulated Raman Scattering Microscopy for Label-Free Chemical Imaging," Optics & Photonics News 20(12), 30 DOI: 10.1364/opn.20.12.000030 (2009)
Blainey, Paul C; Luo, Guobin; Kou, S C; Mangel, Walter F; Verdine, Gregory L; Bagchi, Biman; Xie, X Sunney "Nonspecifically bound proteins spin while diffusing along DNA," Nature Structural & Molecular Biology 16(12), 1224-1229 DOI: 10.1038/nsmb.1716 (2009)
Lu, Ju; Min, Wei; Conchello, José-Angel; Xie, Xiaoliang Sunney; Lichtman, Jeff W. "Super-Resolution Laser Scanning Microscopy through Spatiotemporal Modulation," Nano Lett. 9(11), 3883-3889 DOI: 10.1021/nl902087d (2009)
Min, Wei; Lu, Sijia; Chong, Shasha; Roy, Rahul; Holtom, Gary R.; Xie, X. Sunney "Imaging chromophores with undetectable fluorescence by stimulated emission microscopy," Nature 461(7267), 1105-1109 DOI: 10.1038/nature08438 (2009)
Lyn, Rodney K.; Kennedy, David C.; Sagan, Selena M.; Blais, David R.; Rouleau, Yanouchka; Pegoraro, Adrian F.; Xie, X. Sunney; Stolow, Albert; Pezacki, John Paul "Direct imaging of the disruption of hepatitis C virus replication complexes by inhibitors of lipid metabolism," Virology 394(1), 130-142 DOI: 10.1016/j.virol.2009.08.022 (2009)
Min, Wei; Xie, X. Sunney; Bagchi, Biman "Role of conformational dynamics in kinetics of an enzymatic cycle in a nonequilibrium steady state," J. Chem. Phys. 131(6), 065104 DOI: 10.1063/1.3207274 (2009)
Sims, Peter A.; Xie, X. Sunney "Probing Dynein and Kinesin Stepping with Mechanical Manipulation in a Living Cell," ChemPhysChem 10(9-10), 1511-1516 DOI: 10.1002/cphc.200900113 (2009)
Saar, Brian G.; Holtom, Gary R.; Freudiger, Christian W.; Ackermann, Chrisita; Hill, Winfield; Xie, X. Sunney "Intracavity wavelength modulation of an optical parametric oscillator for coherent Raman microscopy," Optics Express 17(15), 12532 DOI: 10.1364/oe.17.012532 (2009)
Kieu, Khanh; Saar, Brian G.; Holtom, Gary R.; Xie, X. Sunney; Wise, Frank W. "High-power picosecond fiber source for coherent Raman microscopy," Opt. Lett. 34(13), 2051 DOI: 10.1364/ol.34.002051 (2009)
Min, Wei; Lu, Sijia; Rueckel, Markus; Holtom, Gary R.; Xie, X. Sunney "Near-Degenerate Four-Wave-Mixing Microscopy," Nano Lett. 9(6), 2423-2426 DOI: 10.1021/nl901101g (2009)
Min, Wei; Lu, Sijia; Holtom, Gary R.; Xie, X. Sunney "Triple-Resonance Coherent Anti-Stokes Raman Scattering Microspectroscopy," ChemPhysChem 10(2), 344-347 DOI: 10.1002/cphc.200800502 (2009)
Murugkar, S.; Evans, C. L.; Xie, X. S.; Anis, H. "Chemically specific imaging of cryptosporidium oocysts using coherent anti-Stokes Raman scattering (CARS) microscopy," Journal of Microscopy 233(2), 244-250 DOI: 10.1111/j.1365-2818.2009.03114.x (2009)
Freudiger, C. W.; Min, W.; Saar, B. G.; Lu, S.; Holtom, G. R.; He, C.; Tsai, J. C.; Kang, J. X.; Xie, X. S. "Label-Free Biomedical Imaging with High Sensitivity by Stimulated Raman Scattering Microscopy," Science 322(5909), 1857-1861 DOI: 10.1126/science.1165758 (2008)
Choi, P. J.; Cai, L.; Frieda, K.; Xie, X. S. "A Stochastic Single-Molecule Event Triggers Phenotype Switching of a Bacterial Cell," Science 322(5900), 442-446 DOI: 10.1126/science.1161427 (2008)
Xie, X. Sunney; Choi, Paul J.; Li, Gene-Wei; Lee, Nam Ki; Lia, Giuseppe "Single-Molecule Approach to Molecular Biology in Living Bacterial Cells," Annual Review of Biophysics 37(1), 417-444 DOI: 10.1146/annurev.biophys.37.092607.174640 (2008)
Evans, Conor L.; Xie, X. Sunney "Coherent Anti-Stokes Raman Scattering Microscopy: Chemical Imaging for Biology and Medicine," Annual Review of Analytical Chemistry 1(1), 883-909 DOI: 10.1146/annurev.anchem.1.031207.112754 (2008)
Nan, Xiaolin; Sims, Peter A.; Xie, X. Sunney "Organelle Tracking in a Living Cell with Microsecond Time Resolution and Nanometer Spatial Precision," ChemPhysChem 9(5), 707-712 DOI: 10.1002/cphc.200700839 (2008)
Li, J. J.; Chu, Y.; Lee, B. Y.-H.; Xie, X. S. "Enzymatic signal amplification of molecular beacons for sensitive DNA detection," Nucleic Acids Research 36(6), e36-e36 DOI: 10.1093/nar/gkn033 (2008)
Bagchi, Biman; Blainey, Paul C.; Xie, X. Sunney " Diffusion Constant of a Nonspecifically Bound Protein Undergoing Curvilinear Motion along DNA," J. Phys. Chem. B 112(19), 6282-6284 DOI: 10.1021/jp077568f (2008)
Min, Wei; Xie, X. Sunney; Bagchi, Biman " Two-Dimensional Reaction Free Energy Surfaces of Catalytic Reaction: Effects of Protein Conformational Dynamics on Enzyme Catalysis † ," J. Phys. Chem. B 112(2), 454-466 DOI: 10.1021/jp076533c (2008)
Wright, A. J.; Poland, S. P.; Girkin, J. M.; Freudiger, C. W.; Evans, C. L.; Xie, X. S. "Adaptive optics for enhanced signal in CARS microscopy," Optics Express 15(26), 18209 DOI: 10.1364/oe.15.018209 (2007)
Saar, Brian G.; Park, Heung-Shik; Xie, X. S.; Lavrentovich, Oleg D. "Three-dimensional imaging of chemical bond orientation in liquid crystals by coherent anti- Stokes Raman scattering microscopy," Optics Express 15(21), 13585 DOI: 10.1364/oe.15.013585 (2007)
Evans, Conor L.; Xu, Xiaoyin; Kesari, Santosh; Xie, X. Sunney; Wong, Stephen T.C.; Young, Geoffrey S. "Chemically-selective imaging of brain structures with CARS microscopy," Optics Express 15(19), 12076 DOI: 10.1364/oe.15.012076 (2007)
Luo, G.; Wang, M.; Konigsberg, W. H.; Xie, X. S. "Single-molecule and ensemble fluorescence assays for a functionally important conformational change in T7 DNA polymerase," Proceedings of the National Academy of Sciences 104(31), 12610-12615 DOI: 10.1073/pnas.0700920104 (2007)
Kim, Sangjin; Blainey, Paul C; Schroeder, Charles M; Xie, X Sunney "Multiplexed single-molecule assay for enzymatic activity on flow-stretched DNA," Nature Methods 4, 397-399 DOI: 10.1038/nmeth1037 (2007)
Elf, J.; Li, G.-W.; Xie, X. S. "Probing Transcription Factor Dynamics at the Single-Molecule Level in a Living Cell," Science 316(5828), 1191-1194 DOI: 10.1126/science.1141967 (2007)
Friedman, Nir; Cai, Long; Xie, X. Sunney "Linking Stochastic Dynamics to Population Distribution: An Analytical Framework of Gene Expression," Physical Review Letters 97(16) DOI: 10.1103/physrevlett.97.168302 (2006)
Min, Wei; Gopich, Irina V.; English, Brian P.; Kou, S. C.; Xie, X. Sunney; Szabo, Attila "When Does the Michaelis−Menten Equation Hold for Fluctuating Enzymes?," J. Phys. Chem. B 110(41), 20093-20097 DOI: 10.1021/jp065187g (2006)
Qian, Hong; Sunney Xie, X. "Generalized Haldane equation and fluctuation theorem in the steady-state cycle kinetics of single enzymes," Phys. Rev. E 74(1) DOI: 10.1103/physreve.74.010902 (2006)
Nan, Xiaolin; Potma, Eric O.; Xie, X. Sunney "Nonperturbative Chemical Imaging of Organelle Transport in Living Cells with Coherent Anti-Stokes Raman Scattering Microscopy," Biophysical Journal 91(2), 728-735 DOI: 10.1529/biophysj.105.074534 (2006)
Luo, Guobin; Andricioaei, Ioan; Xie, X. Sunney; Karplus, Martin "Dynamic Distance Disorder in Proteins Is Caused by Trapping," J. Phys. Chem. B 110(19), 9363-9367 DOI: 10.1021/jp057497p (2006)
Ganikhanov, Feruz; Evans, Conor L.; Saar, Brian G.; Xie, X. Sunney "High-sensitivity vibrational imaging with frequency modulation coherent anti-Stokes Raman scattering (FM CARS) microscopy," Opt. Lett. 31(12), 1872 DOI: 10.1364/ol.31.001872 (2006)
Nan, Xiaolin; Tonary, Angela M; Stolow, Albert; Xie, X. Sunney; Pezacki, John P "Intracellular Imaging of HCV RNA and Cellular Lipids by Using Simultaneous Two-Photon Fluorescence and Coherent Anti-Stokes Raman Scattering Microscopies," ChemBioChem 7, 1895-1897 DOI: (2006)
Légaré, François; Evans, Conor L.; Ganikhanov, Feruz; Xie, X. S. "Towards CARS Endoscopy," Optics Express 14(10), 4427 DOI: 10.1364/oe.14.004427 (2006)
Ganikhanov, Feruz; Carrasco, Silvia; Sunney Xie, X.; Katz, Mordechai; Seitz, Wolfgang; Kopf, Daniel "Broadly tunable dual-wavelength light source for coherent anti-Stokes Raman scattering microscopy," Opt. Lett. 31(9), 1292 DOI: 10.1364/ol.31.001292 (2006)
Xie, X. S. "Living Cells as Test Tubes," Science 312(5771), 228-230 DOI: 10.1126/science.1127566 (2006)
Blainey, P. C.; van Oijen, A. M.; Banerjee, A.; Verdine, G. L.; Xie, X. S. "A base-excision DNA-repair protein finds intrahelical lesion bases by fast sliding in contact with DNA," Proceedings of the National Academy of Sciences 103(15), 5752-5757 DOI: 10.1073/pnas.0509723103 (2006)
Lee, Jong-Bong; Hite, Richard K.; Hamdan, Samir M.; Sunney Xie, X.; Richardson, Charles C.; van Oijen, Antoine M. "DNA primase acts as a molecular brake in DNA replication," Nature 439(7076), 621-624 DOI: 10.1038/nature04317 (2006)
Rakic, Bojana; Sagan, Selena M.; Noestheden, Matthew; Bélanger, Sylvie; Nan, Xiaolin; Evans, Conor L.; Xie, X. Sunney; Pezacki, John Paul "Peroxisome Proliferator-Activated Receptor α Antagonism Inhibits Hepatitis C Virus Replication," Chemistry & Biology 13(1), 23-30 DOI: 10.1016/j.chembiol.2005.10.006 (2006)
Yu, Ji; Xiao, Jie; Lao, Kaiqin; Xie, X. Sunney "Probing Gene Expression in Live Cells, One Protein Molecule at a Time," Science 311(5767), 1600-1603 DOI: 10.1126/science.1119623 (2006)
Cai, Long; Friedman, Nir; Xie, X. Sunney "Stochastic protein expression in individual cells at the single molecule level," Nature 440(7082), 358-362 DOI: 10.1038/nature04599 (2006)
Min, Wei; Xie, X. Sunney "Kramers model with a power-law friction kernel: Dispersed kinetics and dynamic disorder of biochemical reactions," Phys. Rev. E 73(1) DOI: 10.1103/physreve.73.010902 (2006)
English, Brian P; Min, Wei; van Oijen, Antoine M; Lee, Kang Taek; Luo, Guobin; Sun, Hongye; Cherayil, Binny J; Kou, S C; Xie, X Sunney "Ever-fluctuating single enzyme molecules: Michaelis-Menten equation revisited," Nat Chem Biol 2(2), 87-94 DOI: 10.1038/nchembio759 (2006)
Potma, Eric O.; Evans, Conor L.; Xie, X. Sunney "Heterodyne coherent anti-Stokes Raman scattering (CARS) imaging," Opt. Lett. 31(2), 241 DOI: 10.1364/ol.31.000241 (2006)
Nan, Xiaolin; Sims, Peter A.; Chen, Peng; Xie, X. Sunney "Observation of Individual Microtubule Motor Steps in Living Cells with Endocytosed Quantum Dots," J. Phys. Chem. B 109(51), 24220-24224 DOI: 10.1021/jp056360w (2005)
Min, Wei; Jiang, Liang; Yu, Ji; Kou, S. C.; Qian, Hong; Xie, X. Sunney "Nonequilibrium Steady State of a Nanometric Biochemical System: Determining the Thermodynamic Driving Force from Single Enzyme Turnover Time Traces," Nano Lett. 5(12), 2373-2378 DOI: 10.1021/nl0521773 (2005)
Min, Wei; English, Brian P.; Luo, Guobin; Cherayil, Binny J.; Kou, S. C.; Xie, X. Sunney "Fluctuating Enzymes: Lessons from Single-Molecule Studies," Acc. Chem. Res. 38(12), 923-931 DOI: 10.1021/ar040133f (2005)
Debnath, Pallavi; Min, Wei; Xie, X. Sunney; Cherayil, Binny J. "Multiple time scale dynamics of distance fluctuations in a semiflexible polymer: A one-dimensional generalized Langevin equation treatment," J. Chem. Phys. 123(20), 204903 DOI: 10.1063/1.2109809 (2005)
Evans, C. L.; Potma, E. O.; Puoris'haag, M.; Cote, D.; Lin, C. P.; Xie, X. S. "Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy," Proceedings of the National Academy of Sciences 102(46), 16807-16812 DOI: 10.1073/pnas.0508282102 (2005)
Kou, S. C.; Cherayil, Binny J.; Min, Wei; English, Brian P.; Xie, X. Sunney "Single-Molecule Michaelis−Menten Equations," J. Phys. Chem. B 109(41), 19068-19081 DOI: 10.1021/jp051490q (2005)
Krug, John T.; Sánchez, Erik J.; Xie, X. Sunney "Fluorescence quenching in tip-enhanced nonlinear optical microscopy," Applied Physics Letters 86(23), 233102 DOI: 10.1063/1.1935769 (2005)
Potma, Eric O.; Xie, X. Sunney "Direct Visualization of Lipid Phase Segregation in Single Lipid Bilayers with Coherent Anti-Stokes Raman Scattering Microscopy," ChemPhysChem 6(1), 77-79 DOI: 10.1002/cphc.200400390 (2005)
Kou, S. C.; Sunney Xie, X.; Liu, Jun S. "Bayesian analysis of single-molecule experimental data (with discussion)," Journal of the Royal Statistical Society: Series C (Applied Statistics) 54(3), 469-506 DOI: 10.1111/j.1467-9876.2005.00509.x (2005)
Min, Wei; Luo, Guobin; Cherayil, Binny J.; Kou, S. C.; Xie, X. Sunney "Observation of a Power-Law Memory Kernel for Fluctuations within a Single Protein Molecule," Physical Review Letters 94(19) DOI: 10.1103/physrevlett.94.198302 (2005)
Evans, Conor L.; Potma, Eric O.; Xie, X. Sunney "Coherent anti-Stokes Raman scattering spectral interferometry: determination of the real and imaginary components of nonlinear susceptibility χ^(3) for vibrational microscopy," Opt. Lett. 29(24), 2923 DOI: 10.1364/ol.29.002923 (2004)
Potma, Eric O.; Xie, X. Sunney "CARS Microscopy for Biology and Medicine," Optics & Photonics News 15(11), 40 DOI: 10.1364/opn.15.11.000040 (2004)
Kou, S. C.; Xie, X. Sunney "Generalized Langevin Equation with Fractional Gaussian Noise: Subdiffusion within a Single Protein Molecule," Physical Review Letters 93(18) DOI: 10.1103/physrevlett.93.180603 (2004)
Potma, Eric O.; Xie, X. Sunney; Muntean, Ligia; Preusser, Jan; Jones, David; Ye, Jun; Leone, Stephen R.; Hinsberg, William D.; Schade, Wolfgang "Chemical Imaging of Photoresists with Coherent Anti-Stokes Raman Scattering (CARS) Microscopy," J. Phys. Chem. B 108(4), 1296-1301 DOI: 10.1021/jp030903p (2004)
Cheng, Ji-Xin; Xie, X. Sunney "Coherent Anti-Stokes Raman Scattering Microscopy: Instrumentation, Theory, and Applications," J. Phys. Chem. B 108(3), 827-840 DOI: 10.1021/jp035693v (2004)
Cotlet, M.; Masuo, S.; Luo, G.; Hofkens, J.; Van der Auweraer, M.; Verhoeven, J.; Mullen, K.; Xie, X. S.; De Schryver, F. "Probing conformational dynamics in single donor-acceptor synthetic molecules by means of photoinduced reversible electron transfer," Proceedings of the National Academy of Sciences 101(40), 14343-14348 DOI: 10.1073/pnas.0406119101 (2004)
Nan, Xiaolin; Yang, Wei Yuan; Xie, X. Sunney "CARS Microscopy: Lights Up Lipids in Living Cells," Biophotonics International 11(44) DOI: (2004)
Rech, I.; Luo, G.; Ghioni, M.; Yang, H.; Xie, X.S.; Cova, S. "Photon-Timing Detector Module for Single-Molecule Spectroscopy With 60-ps Resolution," IEEE Journal of Selected Topics in Quantum Electronics 10(4), 788-795 DOI: 10.1109/jstqe.2004.833975 (2004)
Louie, Tai Man; Xie, X. Sunney; Xun, Luying " Coordinated Production and Utilization of FADH 2 by NAD(P)H−Flavin Oxidoreductase and 4-Hydroxyphenylacetate 3-Monooxygenase † ," Biochemistry 42(24), 7509-7517 DOI: 10.1021/bi034092r (2003)
Dufresne, E. R.; Corwin, E. I.; Greenblatt, N. A.; Ashmore, J.; Wang, D. Y.; Dinsmore, A. D.; Cheng, J. X.; Xie, X. S.; Hutchinson, J. W.; Weitz, D. A. "Flow and Fracture in Drying Nanoparticle Suspensions," Physical Review Letters 91(22) DOI: 10.1103/physrevlett.91.224501 (2003)
Pautot, Sophie; Frisken, Barbara J.; Cheng, Ji-Xin; Xie, X. Sunney; Weitz, D. A. "Spontaneous Formation of Lipid Structures at Oil/Water/Lipid Interfaces," Langmuir 19(24), 10281-10287 DOI: 10.1021/la034532f (2003)
Nan, X.; Cheng, Ji-Xin; Xie, X. Sunney Xie "Vibrational imaging of lipid droplets in live fibroblast cells with coherent anti-Stokes Raman scattering microscopy," The Journal of Lipid Research 44(11), 2202-2208 DOI: 10.1194/jlr.d300022-jlr200 (2003)
Yang, Haw; Luo, Guobin; Karnchanaphanurach, Pallop; Louie, Tai-Man; Rech, Ivan; Cova, Sergio; Xun, Luying; Xie, X. Sunney "Protein Conformational Dynamics Probed by Single-Molecule Electron Transfer," Science 302(5643), 262-266 DOI: 10.1126/science.1086911 (2003)
Potma, Eric O.; Xie, X. S. "Detection of single lipid bilayers with coherent anti-Stokes Raman scattering (CARS) microscopy," Journal of Raman Spectroscopy 34(9), 642-650 DOI: 10.1002/jrs.1045 (2003)
Potma, Eric O.; Evans, Conor; Xie, X. Sunney; Jones, R. Jason; Ye, Jun "Picosecond-pulse amplification with an external passive optical cavity," Opt. Lett. 28(19), 1835 DOI: 10.1364/ol.28.001835 (2003)
van Oijen, Antoine M.; Blainey, Paul C.; Crampton, Donald J.; Richardson, Charles C.; Ellenberger, Tom; Xie, X. Sunney "Single-Molecule Kinetics of Exonuclease Reveal Base Dependence and Dynamic Disorder," Science 301(5637), 1235-1238 DOI: 10.1126/science.1084387 (2003)
Cheng, J.-X.; Pautot, S.; Weitz, D. A.; Xie, X. S. "Ordering of water molecules between phospholipid bilayers visualized by coherent anti-Stokes Raman scattering microscopy," Proceedings of the National Academy of Sciences 100(17), 9826-9830 DOI: 10.1073/pnas.1732202100 (2003)
Hartschuh, Achim; Sánchez, Erik J.; Xie, X. Sunney; Novotny, Lukas "High-Resolution Near-Field Raman Microscopy of Single-Walled Carbon Nanotubes," Physical Review Letters 90(9) DOI: 10.1103/physrevlett.90.095503 (2003)
Yang, Haw; Xie, X. Sunney "Probing single-molecule dynamics photon by photon," J. Chem. Phys 117, 10965 DOI: (2002)
Xie, X. Sunney "Single-molecule approach to dispersed kinetics and dynamic disorder: Probing conformational fluctuation and enzymatic dynamics," J. Chem. Phys 117, 11024 DOI: (2002)
Yang, Haw; Xie, X. Sunney "Probing Single Molecule Dynamics Photon by Photon," J. Chem. Phys 117, 10965 DOI: (2002)
Sánchez, Eric J; Krug, John T. II; Xie, X. Sunney "Ion and Electron Beam Assisted Growth of Nanometeric SimOn Structures for Near-Field Microscopy," Rev. Sci. Instr 73, 3901 DOI: (2002)
Luoie, Tai Man; Yang, Haw; Karnchanaphanurach, Pallop; Xie, X. Sunney; Xun, Luying "FAD is a Preferred Substrate and an Inhibitor of Escherichia coli General NAD(P)H: flavin Oxidoreductase," J. Biol. Chem 277, 39450 DOI: (2002)
Yang, Haw; Xie, X. Sunney "Statistical Approaches for Probing Single-molecule Dynamics Photon-by-Photon," Chem. Phys 284, 423 DOI: (2002)
Cheng, Ji-Xin; Volkmer, Andreas; Book, Lewis D; Xie, X. Sunney "Multiplex Coherent Anti-Stokes Raman Scattering Microspectroscopy and Study of Lipid Vesicles," J. Phys. Chem. B 106, 8493 DOI: (2002)
Cheng, Ji-Xin; Potma, Eric O; Xie, X. Sunney "Coherent Anti-Stokes Raman Scattering Correlation Spectroscopy: Probing Dynamical Processes with Chemical Selectivity," J. Phys. Chem. A 106, 8561 DOI: (2002)
Jones, David J; Potma, Eric O; Cheng, Ji-Xin; Burfeindt, Berndt; Pang, Yang; Ye, Jun; Xie, X. Sunney "Synchronization of two passively mode-locked, picosecond lasers within 20 fs for coherent anti-Stokes Raman scattering microscopy," Rev. Sci. Instrum 73, 2843 DOI: (2002)
Cheng, Ji-Xin; Xie, X. Sunney "Green's function formulation for third-harmonic generation microscopy," JOSAB 19, 1604 DOI: (2002)
Potma, Eric O; Jones, David J; Cheng, Ji-Xin; Xie, X. Sunney; Ye, Jun "High-sensitivity coherent anti-Stokes Raman scattering microscopy with two tightly synchronized picosecond lasers," Optics Lett 27, 1168 DOI: (2002)
Cheng, Ji-Xin; Jia, Y. Kevin; Zheng, Gengfeng; Xie, X. Sunney "Laser-Scanning Coherent Anti-Stokes Raman Scattering Microscopy and Applications to Cell Biology," Biophys. J 83, 502 DOI: (2002)
Cheng, Ji-Xin; Volkmer, Andreas; Xie, X. Sunney "Theoretical and experimental characterization of coherent anti-Stokes Raman scattering microscopy," JOSA B 19, 1363 DOI: (2002)
Krug, John T. II; Sánchez, Erik J; Xie, X. Sunney "Design of near-field probes with optimal field enhancement by finite difference time domain electromagnetic simulation," J. Chem. Phys 116(24), 10895 DOI: (2002)
Volkmer, Andreas; Book, Lewis D; Xie, X. Sunney "Time-resolved coherent anti-Stokes Raman scattering microscopy: Imaging based on Raman free induction decay," Appl. Phys. Lett 80, 1505 DOI: (2002)
Xie, Sunney "Single-Molecule Approach to Enzymology," Single Mol. 2(4), 229-236 DOI: 10.1002/1438-5171(200112)2:4<229::aid-simo229>3.0.co;2-9 (2001)
Cheng, Ji-Xin; Book, Lewis D.; Xie, X. Sunney "Polarization coherent anti-Stokes Raman scattering microscopy," Opt. Lett. 26(17), 1341 DOI: 10.1364/ol.26.001341 (2001)
Volkmer, Andreas; Cheng, Ji-Xin; Xie, X. Sunney "Vibrational Imaging with High Sensitivity via Epidetected Coherent Anti-Stokes Raman Scattering Microscopy," Physical Review Letters 87(2) DOI: 10.1103/physrevlett.87.023901 (2001)
Cheng, Ji-xin; Volkmer, Andreas; Book, Lewis D.; Xie, X. Sunney "An Epi-Detected Coherent Anti-Stokes Raman Scattering (E-CARS) Microscope with High Spectral Resolution and High Sensitivity," J. Phys. Chem. B 105(7), 1277-1280 DOI: 10.1021/jp003774a (2001)
Schenter, Gregory K.; Lu, H. Peter; Xie, X. Sunney "Statistical Analyses and Theoretical Models of Single-Molecule Enzymatic Dynamics," J. Phys. Chem. A 103(49), 10477-10488 DOI: (1999)
Zumbusch, Andreas; Holtom, Cary R.; Xie, X. Sunney "Three-Dimensional Vibrational Imaging by Coherent Anti-Stokes Raman Scattering," Physical Review Letters 82, 4142-4145 DOI: (1999)
Xie, X. Sunney; Lu, H. Peter "Single-Molecule Enzymology," J. Biol. Chem 274, 15967 DOI: (1999)
Schenter, Greg K; Lu, H. Peter; Xie, X. Sunney "Statistical Analysis and Theoretical Models of Single-Molecule Enzymatic Dynamics," J. Phys. Chem. A 103, 10477 DOI: (1999)
Bai, Chunli; Wang, Chen; Xie, X. Sunney; Wolynes, Peter, G "Single Molecule Physics and Chemistry," Proc. Natl. Acad. Sci. USA 96, 10477 DOI: (1999)
Zumbusch, Andreas; Holtom, Gary R; Xie, X. Sunney "Vibrational Microscopy Using Coherent Anti-Stokes Raman Scattering," Phys. Rev. Lett 82, 4142 DOI: (1999)
Sánchez, Erik J; Novotny, Lukas; Xie, X. Sunney "Near-field Fluorescence Microscopy Based on Two-Photon Excitation With Metal Tips," Phys. Rev. Lett 82, 4014 DOI: (1999)
Ying, L; Xie, X. Sunney "Optical Detection of Single Molecule and its Applications," Daxue Huaxue 14, 1 DOI: (1999)
Lu, H. Peter; Xie, X. Sunney "Single-Molecule Spectroscopy Studies of Molecular Dynamics in Chemical and Biological Systems," Z. Phys. Chem. (Muenchen) 212, 59 DOI: (1999)
Lu, H. Peter; Xun, Luying; Xie, X. Sunney "Single Molecule Enzymatic Dynamics," Science 282, 1877 DOI: (1998)
Ying, Liming; Xie, X. Sunney "Fluorescence Spectroscopy, Excitation Dynamics and Photochemistry of Single Allophycocyanin Trimers," J. Phys. Chem. B 102, 10399 DOI: (1998)
Xie, X. Sunney; Trautman, Jay K "Optical studies of single molecules at room temperature," Ann. Rev. Phys. Chem 49, 441 DOI: (1998)
Novotny, Lukas; Sanchez, Erik J; Xie, X. Sunney "Near-field Optical Imaging Using Metal Tips Illuminated by Higher-order Hermite-Gaussian Beams," Ultramicroscopy 71, 21 DOI: (1998)
Sanchez, Erik J; Novotny, Lukas; Holtom, G.R; Xie, X. Sunney "Room-Temperature Fluorescence Imaging and Spectroscopy of Single Molecules by Two-Photon Excitation," J. Phys. Chem. A 101, 7019 DOI: (1997)
Novotny, Lukas; Bian, Randy X; Xie, X. Sunney "Theory of Nanometric Optical Tweezers," Phys. Rev. Lett 79, 645 DOI: (1997)
Lu, H. Peter; Xie, X. Sunney "Single-Molecule Kinetics of Interfacial Electron Transfer Temperature," J. Phys. Chem 101, 2753 DOI: (1997)
Lu, H. Peter; Xie, X. Sunney "Single-Molecule Spectral Fluctuations at Room Temperature," Nature 385, 143 DOI: (1997)
Xie, X. Sunney "Single-Molecule Spectroscopy and Dynamics at Room Temperature," Acc. Chem. Res 29, 598 DOI: (1996)
Bian, Randy X; Dunn, Robert C; Xie, X. Sunney; Leung, P. T "Single molecule emission characteristics in near-field microscopy," Phys. Rev. Lett 75, 4772 DOI: (1995)
Holtom, Gary R; Crowell, Robert A; Xie, X. Sunney "A High Repetition Rate Femtosecond Optical Parametric Oscillator-Amplifier System Near 3 Microns," J. Optic. Soc. Am. B 12, 1723 DOI: (1995)
Dunn, Robert C; Xie, X. Sunney "Characterization of the Temporal Behavior of Ultrashort Pulses Emerging from a Near-field Fiber Probe," Ultramicroscopy 57, 169 DOI: (1995)
Dunn, Robert C; Allen, Errol V; Joyce, Stephen A; Anderson, Gordon A; Xie, X. Sunney "Near-field Fluorescent Imaging of Single Proteins," Ultramicroscopy 57, 113 DOI: (1995)
Crowell, Robert A; Holtom, Gary R; Xie, X. Sunney "The Infrared Free Induction Decay of Liquid Water Molecules," J. Phys. Chem 99, 1840 DOI: (1995)
Xie, X. Sunney; Dunn, Robert C "Probing Single Molecule Dynamics," Science 265, 361 DOI: (1994)
Crowell, Robert A; Holtom, Gary R; Xie, X. Sunney "Liquid Water Dynamics Probed by Femtosecond Infrared Spectroscopy," Ultrafast Phenomena IX (Springer-Verlag) 156 DOI: (1994)
Xie, X. Sunney; Holtom, Gary R; Mets, Laurens; Dunn, Robert C "Near-field Time-Resolved Spectroscopy on Single Molecules and Photosynthetic Membranes," Ultrafast Phenomena IX (Springer-Verlag) 124 DOI: (1994)
Dunn, Robert C; Holtom, Gary R; Mets, Laurens; Xie, X. Sunney "Near-Field Fluorescence Imaging and Florescence Lifetime Measurements of Light Harvesting Complexes in Intact Photosynthetic Membranes," J. Phys. Chem 98, 3094 DOI: (1994)