Publications

Wang, W.; Li, G.; Chen, C.; Xie, X.S.; Zhuang, X. Chromosome Organization by a Nucleoid-Associated Protein in Live Bacteria. Science 2011, 333(6048), 1445-1449 DOI: 10.1126/science.1204697
Li, G.; Xie, X.S. Central dogma at the single-molecule level in living cells. Nature 2011, 475(7356), 308-315 DOI: 10.1038/nature10315
Saar, B.G.; Johnston, R.S.; Freudiger, C.W.; Xie, X.S.; Seibel, E.J. Coherent Raman scanning fiber endoscopy. Opt. Lett. 2011, 36(13), 2396 DOI: 10.1364/ol.36.002396
Sims, P.A.; Greenleaf, W.J.; Duan, H.; Xie, X.S. Fluorogenic DNA sequencing in PDMS microreactors. Nat Meth 2011, 8(7), 575-580 DOI: 10.1038/nmeth.1629
Saar, B.G.; Contreras-Rojas, L.R.; Xie, X.S.; Guy, R.H. Imaging Drug Delivery to Skin with Stimulated Raman Scattering Microscopy. Mol. Pharm. 2011, 8(3), 969-975 DOI: 10.1021/mp200122w
Freudiger, C.W.; Roeffaers, M.B.J.; Zhang, X.; Saar, B.G.; Min, W.; Xie, X.S. Optical Heterodyne-Detected Raman-Induced Kerr Effect (OHD-RIKE) Microscopy. J. Phys. Chem. B 2011, 115(18), 5574-5581 DOI: 10.1021/jp1113834
Min, W.; Freudiger, C.W.; Lu, S.; Xie, X.S. Coherent Nonlinear Optical Imaging: Beyond Fluorescence Microscopy. Annu. Rev. Phys. Chem. 2011, 62(1), 507-530 DOI: 10.1146/annurev.physchem.012809.103512
Roeffaers, M.B.J.; Zhang, X.; Freudiger, C.W.; Saar, B.G.; Ruijven, M.v.; Dalen, G.v.; Xiao, C.; Xie, X.S. Label-free imaging of biomolecules in food products using stimulated Raman microscopy. J Biomed Opt 2011, 16(2), 021118 DOI: 10.1117/1.3516591
Freudiger, C.W.; Min, W.; Holtom, G.R.; Xu, B.; Dantus, M.; Sunney Xie, X. Highly specific label-free molecular imaging with spectrally tailored excitation-stimulated Raman scattering (STE-SRS) microscopy. Nature Photon 2011, 5(2), 103-109 DOI: 10.1038/nphoton.2010.294
Wang, M.C.; Min, W.; Freudiger, C.W.; Ruvkun, G.; Xie, X.S. RNAi screening for fat regulatory genes with SRS microscopy. Nat Meth 2011, 8(2), 135-138 DOI: 10.1038/nmeth.1556
Taniguchi, Y.; Choi, P.J.; Li, G.; Chen, H.; Babu, M.; Hearn, J.; Emili, A.; Xie, X.S. Quantifying E. coli Proteome and Transcriptome with Single-Molecule Sensitivity in Single Cells. Science 2010, 329(5991), 533-538 DOI: 10.1126/science.1188308
Saar, B.G.; Freudiger, C.W.; Reichman, J.; Stanley, C.M.; Holtom, G.R.; Xie, X.S. Video-Rate Molecular Imaging in Vivo with Stimulated Raman Scattering. Science 2010, 330(6009), 1368-1370 DOI: 10.1126/science.1197236
Chong, S.; Min, W.; Xie, X.S. Ground-State Depletion Microscopy: Detection Sensitivity of Single-Molecule Optical Absorption at Room Temperature. J. Phys. Chem. Lett. 2010, 1(23), 3316-3322 DOI: 10.1021/jz1014289
Wang, K.; Freudiger, C.W.; Lee, J.H.; Saar, B.G.; Xie, X.S.; Xu, C. Synchronized time-lens source for coherent Raman scattering microscopy. Opt. Express 2010, 18(23), 24019 DOI: 10.1364/oe.18.024019
Xie, X.S. Single Molecule Spectroscopy in Chemistry, Physics and Biology. Springer Series in Chemical Physics 2010, DOI: 10.1007/978-3-642-02597-6
Choi, P.J.; Xie, X.S.; Shakhnovich, E.I. Stochastic Switching in Gene Networks Can Occur by a Single-Molecule Event or Many Molecular Steps. J. Mol. Biol. 2009, 396(1), 230-244 DOI: 10.1016/j.jmb.2009.11.035
Saar, B.G.; Zeng, Y.; Freudiger, C.W.; Liu, Y.; Himmel, M.E.; Xie, X.S.; Ding, S. Label-Free, Real-Time Monitoring of Biomass Processing with Stimulated Raman Scattering Microscopy. Angew. Chem. Int. Ed. 2010, 49(32), 5476-5479 DOI: 10.1002/anie.201000900
Min, W.; Jiang, L.; Xie, X.S. Complex Kinetics of Fluctuating Enzymes: Phase Diagram Characterization of a Minimal Kinetic Scheme. Chemistry - An Asian Journal 2010, 5(5), 1129-1138 DOI: 10.1002/asia.200900627
Lu, S.; Min, W.; Chong, S.; Holtom, G.R.; Xie, X.S. Label-free imaging of heme proteins with two-photon excited photothermal lens microscopy. Appl. Phys. Lett. 2010, 96(11), 113701 DOI: 10.1063/1.3308485
Zeng, Y.; Saar, B.G.; Friedrich, M.G.; Chen, F.; Liu, Y.; Dixon, R.A.; Himmel, M.E.; Xie, X.S.; Ding, S. Imaging Lignin-Downregulated Alfalfa Using Coherent Anti-Stokes Raman Scattering Microscopy. Bioenerg. Res. 2010, 3(3), 272-277 DOI: 10.1007/s12155-010-9079-1
Kim, S.; Schroeder, C.M.; Xie, X.S. Single-Molecule Study of DNA Polymerization Activity of HIV-1 Reverse Transcriptase on DNA Templates. J. Mol. Biol. 2010, 395(5), 995-1006 DOI: 10.1016/j.jmb.2009.11.072
Freudiger, C.W.; Min, W.; Saar, B.G.; Xie, X.S. Stimulated Raman Scattering Microscopy for Label-Free Chemical Imaging. Optics & Photonics News 2009, 20(12), 30 DOI: 10.1364/opn.20.12.000030
Blainey, P.C.; Luo, G.; Kou, S.C.; Mangel, W.F.; Verdine, G.L.; Bagchi, B.; Xie, X.S. Nonspecifically bound proteins spin while diffusing along DNA. Nat. Struct. Mol. Biol. 2009, 16(12), 1224-1229 DOI: 10.1038/nsmb.1716
Lu, J.; Min, W.; Conchello, J.; Xie, X.S.; Lichtman, J.W. Super-Resolution Laser Scanning Microscopy through Spatiotemporal Modulation. Nano Lett. 2009, 9(11), 3883-3889 DOI: 10.1021/nl902087d
Min, W.; Lu, S.; Chong, S.; Roy, R.; Holtom, G.R.; Xie, X.S. Imaging chromophores with undetectable fluorescence by stimulated emission microscopy. Nature 2009, 461(7267), 1105-1109 DOI: 10.1038/nature08438
Lyn, R.K.; Kennedy, D.C.; Sagan, S.M.; Blais, D.R.; Rouleau, Y.; Pegoraro, A.F.; Xie, X.S.; Stolow, A.; Pezacki, J.P. Direct imaging of the disruption of hepatitis C virus replication complexes by inhibitors of lipid metabolism. Virology 2009, 394(1), 130-142 DOI: 10.1016/j.virol.2009.08.022
Min, W.; Xie, X.S.; Bagchi, B. Role of conformational dynamics in kinetics of an enzymatic cycle in a nonequilibrium steady state. J. Chem. Phys. 2009, 131(6), 065104 DOI: 10.1063/1.3207274
Sims, P.A.; Xie, X.S. Probing Dynein and Kinesin Stepping with Mechanical Manipulation in a Living Cell. Chemphyschem 2009, 10(9-10), 1511-1516 DOI: 10.1002/cphc.200900113
Saar, B.G.; Holtom, G.R.; Freudiger, C.W.; Ackermann, C.; Hill, W.; Xie, X.S. Intracavity wavelength modulation of an optical parametric oscillator for coherent Raman microscopy. Opt. Express 2009, 17(15), 12532 DOI: 10.1364/oe.17.012532
Kieu, K.; Saar, B.G.; Holtom, G.R.; Xie, X.S.; Wise, F.W. High-power picosecond fiber source for coherent Raman microscopy. Opt. Lett. 2009, 34(13), 2051 DOI: 10.1364/ol.34.002051
Min, W.; Lu, S.; Rueckel, M.; Holtom, G.R.; Xie, X.S. Near-Degenerate Four-Wave-Mixing Microscopy. Nano Lett. 2009, 9(6), 2423-2426 DOI: 10.1021/nl901101g
Min, W.; Lu, S.; Holtom, G.R.; Xie, X.S. Triple-Resonance Coherent Anti-Stokes Raman Scattering Microspectroscopy. Chemphyschem 2009, 10(2), 344-347 DOI: 10.1002/cphc.200800502
Murugkar, S.; Evans, C.L.; Xie, X.S.; Anis, H. Chemically specific imaging of cryptosporidium oocysts using coherent anti-Stokes Raman scattering (CARS) microscopy. J. Microsc. 2009, 233(2), 244-250 DOI: 10.1111/j.1365-2818.2009.03114.x
Freudiger, C.W.; Min, W.; Saar, B.G.; Lu, S.; Holtom, G.R.; He, C.; Tsai, J.C.; Kang, J.X.; Xie, X.S. Label-Free Biomedical Imaging with High Sensitivity by Stimulated Raman Scattering Microscopy. Science 2008, 322(5909), 1857-1861 DOI: 10.1126/science.1165758
Choi, P.J.; Cai, L.; Frieda, K.; Xie, X.S. A Stochastic Single-Molecule Event Triggers Phenotype Switching of a Bacterial Cell. Science 2008, 322(5900), 442-446 DOI: 10.1126/science.1161427
Xie, X.S.; Choi, P.J.; Li, G.; Lee, N.K.; Lia, G. Single-Molecule Approach to Molecular Biology in Living Bacterial Cells. Annu Rev Biophys 2008, 37(1), 417-444 DOI: 10.1146/annurev.biophys.37.092607.174640
Evans, C.L.; Xie, X.S. Coherent Anti-Stokes Raman Scattering Microscopy: Chemical Imaging for Biology and Medicine. Annu Rev Anal Chem (Palo Alto Calif) 2008, 1(1), 883-909 DOI: 10.1146/annurev.anchem.1.031207.112754
Nan, X.; Sims, P.A.; Xie, X.S. Organelle Tracking in a Living Cell with Microsecond Time Resolution and Nanometer Spatial Precision. Chemphyschem 2008, 9(5), 707-712 DOI: 10.1002/cphc.200700839
Li, J.J.; Chu, Y.; Lee, B.Y.; Xie, X.S. Enzymatic signal amplification of molecular beacons for sensitive DNA detection. Nucleic Acids Res. 2008, 36(6), e36-e36 DOI: 10.1093/nar/gkn033
Bagchi, B.; Blainey, P.C.; Xie, X.S. Diffusion Constant of a Nonspecifically Bound Protein Undergoing Curvilinear Motion along DNA. J. Phys. Chem. B 2008, 112(19), 6282-6284 DOI: 10.1021/jp077568f
Min, W.; Xie, X.S.; Bagchi, B. Two-Dimensional Reaction Free Energy Surfaces of Catalytic Reaction: Effects of Protein Conformational Dynamics on Enzyme Catalysis † . J. Phys. Chem. B 2008, 112(2), 454-466 DOI: 10.1021/jp076533c
Wright, A.J.; Poland, S.P.; Girkin, J.M.; Freudiger, C.W.; Evans, C.L.; Xie, X.S. Adaptive optics for enhanced signal in CARS microscopy. Opt. Express 2007, 15(26), 18209 DOI: 10.1364/oe.15.018209
Saar, B.G.; Park, H.; Xie, X.S.; Lavrentovich, O.D. Three-dimensional imaging of chemical bond orientation in liquid crystals by coherent anti- Stokes Raman scattering microscopy. Opt. Express 2007, 15(21), 13585 DOI: 10.1364/oe.15.013585
Evans, C.L.; Xu, X.; Kesari, S.; Xie, X.S.; Wong, S.T.; Young, G.S. Chemically-selective imaging of brain structures with CARS microscopy. Opt. Express 2007, 15(19), 12076 DOI: 10.1364/oe.15.012076
Luo, G.; Wang, M.; Konigsberg, W.H.; Xie, X.S. Single-molecule and ensemble fluorescence assays for a functionally important conformational change in T7 DNA polymerase. Proc. Natl. Acad. Sci. U.S.A. 2007, 104(31), 12610-12615 DOI: 10.1073/pnas.0700920104
Kim, S.; Blainey, P.C.; Schroeder, C.M.; Xie, X.S. Multiplexed single-molecule assay for enzymatic activity on flow-stretched DNA. Nat. Methods 2007, 4, 397-399 DOI: 10.1038/nmeth1037
Elf, J.; Li, G.; Xie, X.S. Probing Transcription Factor Dynamics at the Single-Molecule Level in a Living Cell. Science 2007, 316(5828), 1191-1194 DOI: 10.1126/science.1141967
Friedman, N.; Cai, L.; Xie, X.S. Linking Stochastic Dynamics to Population Distribution: An Analytical Framework of Gene Expression. Phys. Rev. Lett. 2006, 97(16) DOI: 10.1103/physrevlett.97.168302
Min, W.; Gopich, I.V.; English, B.P.; Kou, S.C.; Xie, X.S.; Szabo, A. When Does the Michaelis−Menten Equation Hold for Fluctuating Enzymes?. J. Phys. Chem. B 2006, 110(41), 20093-20097 DOI: 10.1021/jp065187g
Qian, H.; Sunney Xie, X. Generalized Haldane equation and fluctuation theorem in the steady-state cycle kinetics of single enzymes. Phys. Rev. E 2006, 74(1) DOI: 10.1103/physreve.74.010902
Nan, X.; Potma, E.O.; Xie, X.S. Nonperturbative Chemical Imaging of Organelle Transport in Living Cells with Coherent Anti-Stokes Raman Scattering Microscopy. Biophys. J. 2006, 91(2), 728-735 DOI: 10.1529/biophysj.105.074534
Luo, G.; Andricioaei, I.; Xie, X.S.; Karplus, M. Dynamic Distance Disorder in Proteins Is Caused by Trapping. J. Phys. Chem. B 2006, 110(19), 9363-9367 DOI: 10.1021/jp057497p
Ganikhanov, F.; Evans, C.L.; Saar, B.G.; Xie, X.S. High-sensitivity vibrational imaging with frequency modulation coherent anti-Stokes Raman scattering (FM CARS) microscopy. Opt. Lett. 2006, 31(12), 1872 DOI: 10.1364/ol.31.001872
Nan, X.; Tonary, A.M.; Stolow, A.; Xie, X.S.; Pezacki, J.P. Intracellular Imaging of HCV RNA and Cellular Lipids by Using Simultaneous Two-Photon Fluorescence and Coherent Anti-Stokes Raman Scattering Microscopies. Chembiochem 2006, 7, 1895-1897 DOI:
Légaré, F.; Evans, C.L.; Ganikhanov, F.; Xie, X.S. Towards CARS Endoscopy. Opt. Express 2006, 14(10), 4427 DOI: 10.1364/oe.14.004427
Ganikhanov, F.; Carrasco, S.; Sunney Xie, X.; Katz, M.; Seitz, W.; Kopf, D. Broadly tunable dual-wavelength light source for coherent anti-Stokes Raman scattering microscopy. Opt. Lett. 2006, 31(9), 1292 DOI: 10.1364/ol.31.001292
Xie, X.S. Living Cells as Test Tubes. Science 2006, 312(5771), 228-230 DOI: 10.1126/science.1127566
Blainey, P.C.; van Oijen, A.M.; Banerjee, A.; Verdine, G.L.; Xie, X.S. A base-excision DNA-repair protein finds intrahelical lesion bases by fast sliding in contact with DNA. Proc. Natl. Acad. Sci. U.S.A. 2006, 103(15), 5752-5757 DOI: 10.1073/pnas.0509723103
Lee, J.; Hite, R.K.; Hamdan, S.M.; Sunney Xie, X.; Richardson, C.C.; van Oijen, A.M. DNA primase acts as a molecular brake in DNA replication. Nature 2006, 439(7076), 621-624 DOI: 10.1038/nature04317
Rakic, B.; Sagan, S.M.; Noestheden, M.; Bélanger, S.; Nan, X.; Evans, C.L.; Xie, X.S.; Pezacki, J.P. Peroxisome Proliferator-Activated Receptor α Antagonism Inhibits Hepatitis C Virus Replication. Chem. Biol. 2006, 13(1), 23-30 DOI: 10.1016/j.chembiol.2005.10.006
Yu, J.; Xiao, J.; Lao, K.; Xie, X.S. Probing Gene Expression in Live Cells, One Protein Molecule at a Time. Science 2006, 311(5767), 1600-1603 DOI: 10.1126/science.1119623
Cai, L.; Friedman, N.; Xie, X.S. Stochastic protein expression in individual cells at the single molecule level. Nature 2006, 440(7082), 358-362 DOI: 10.1038/nature04599
Min, W.; Xie, X.S. Kramers model with a power-law friction kernel: Dispersed kinetics and dynamic disorder of biochemical reactions. Phys. Rev. E 2006, 73(1) DOI: 10.1103/physreve.73.010902
English, B.P.; Min, W.; van Oijen, A.M.; Lee, K.T.; Luo, G.; Sun, H.; Cherayil, B.J.; Kou, S.C.; Xie, X.S. Ever-fluctuating single enzyme molecules: Michaelis-Menten equation revisited. Nat Chem Biol 2006, 2(2), 87-94 DOI: 10.1038/nchembio759
Potma, E.O.; Evans, C.L.; Xie, X.S. Heterodyne coherent anti-Stokes Raman scattering (CARS) imaging. Opt. Lett. 2006, 31(2), 241 DOI: 10.1364/ol.31.000241
Nan, X.; Sims, P.A.; Chen, P.; Xie, X.S. Observation of Individual Microtubule Motor Steps in Living Cells with Endocytosed Quantum Dots. J. Phys. Chem. B 2005, 109(51), 24220-24224 DOI: 10.1021/jp056360w
Min, W.; Jiang, L.; Yu, J.; Kou, S.C.; Qian, H.; Xie, X.S. Nonequilibrium Steady State of a Nanometric Biochemical System: Determining the Thermodynamic Driving Force from Single Enzyme Turnover Time Traces. Nano Lett. 2005, 5(12), 2373-2378 DOI: 10.1021/nl0521773
Min, W.; English, B.P.; Luo, G.; Cherayil, B.J.; Kou, S.C.; Xie, X.S. Fluctuating Enzymes: Lessons from Single-Molecule Studies. Acc. Chem. Res. 2005, 38(12), 923-931 DOI: 10.1021/ar040133f
Debnath, P.; Min, W.; Xie, X.S.; Cherayil, B.J. Multiple time scale dynamics of distance fluctuations in a semiflexible polymer: A one-dimensional generalized Langevin equation treatment. J. Chem. Phys. 2005, 123(20), 204903 DOI: 10.1063/1.2109809
Evans, C.L.; Potma, E.O.; Puoris'haag, M.; Cote, D.; Lin, C.P.; Xie, X.S. Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy. Proc. Natl. Acad. Sci. U.S.A. 2005, 102(46), 16807-16812 DOI: 10.1073/pnas.0508282102
Kou, S.C.; Cherayil, B.J.; Min, W.; English, B.P.; Xie, X.S. Single-Molecule Michaelis−Menten Equations. J. Phys. Chem. B 2005, 109(41), 19068-19081 DOI: 10.1021/jp051490q
Krug, J.T.; Sánchez, E.J.; Xie, X.S. Fluorescence quenching in tip-enhanced nonlinear optical microscopy. Appl. Phys. Lett. 2005, 86(23), 233102 DOI: 10.1063/1.1935769
Potma, E.O.; Xie, X.S. Direct Visualization of Lipid Phase Segregation in Single Lipid Bilayers with Coherent Anti-Stokes Raman Scattering Microscopy. Chemphyschem 2005, 6(1), 77-79 DOI: 10.1002/cphc.200400390
Kou, S.C.; Sunney Xie, X.; Liu, J.S. Bayesian analysis of single-molecule experimental data (with discussion). J R Stat Soc Ser C Appl Stat 2005, 54(3), 469-506 DOI: 10.1111/j.1467-9876.2005.00509.x
Min, W.; Luo, G.; Cherayil, B.J.; Kou, S.C.; Xie, X.S. Observation of a Power-Law Memory Kernel for Fluctuations within a Single Protein Molecule. Phys. Rev. Lett. 2005, 94(19) DOI: 10.1103/physrevlett.94.198302
Evans, C.L.; Potma, E.O.; Xie, X.S. Coherent anti-Stokes Raman scattering spectral interferometry: determination of the real and imaginary components of nonlinear susceptibility χ^(3) for vibrational microscopy. Opt. Lett. 2004, 29(24), 2923 DOI: 10.1364/ol.29.002923
Potma, E.O.; Xie, X.S. CARS Microscopy for Biology and Medicine. Optics & Photonics News 2004, 15(11), 40 DOI: 10.1364/opn.15.11.000040
Kou, S.C.; Xie, X.S. Generalized Langevin Equation with Fractional Gaussian Noise: Subdiffusion within a Single Protein Molecule. Phys. Rev. Lett. 2004, 93(18) DOI: 10.1103/physrevlett.93.180603
Potma, E.O.; Xie, X.S.; Muntean, L.; Preusser, J.; Jones, D.; Ye, J.; Leone, S.R.; Hinsberg, W.D.; Schade, W. Chemical Imaging of Photoresists with Coherent Anti-Stokes Raman Scattering (CARS) Microscopy. J. Phys. Chem. B 2004, 108(4), 1296-1301 DOI: 10.1021/jp030903p
Cheng, J.; Xie, X.S. Coherent Anti-Stokes Raman Scattering Microscopy: Instrumentation, Theory, and Applications. J. Phys. Chem. B 2004, 108(3), 827-840 DOI: 10.1021/jp035693v
Cotlet, M.; Masuo, S.; Luo, G.; Hofkens, J.; Van der Auweraer, M.; Verhoeven, J.; Mullen, K.; Xie, X.S.; De Schryver, F. Probing conformational dynamics in single donor-acceptor synthetic molecules by means of photoinduced reversible electron transfer. Proc. Natl. Acad. Sci. U.S.A. 2004, 101(40), 14343-14348 DOI: 10.1073/pnas.0406119101
Nan, X.; Yang, W.Y.; Xie, X.S. CARS Microscopy: Lights Up Lipids in Living Cells. Biophotonics Int. 2004, 11(44) DOI:
Rech, I.; Luo, G.; Ghioni, M.; Yang, H.; Xie, X.; Cova, S. Photon-Timing Detector Module for Single-Molecule Spectroscopy With 60-ps Resolution. IEEE J Sel Top Quantum Electron 2004, 10(4), 788-795 DOI: 10.1109/jstqe.2004.833975
Louie, T.M.; Xie, X.S.; Xun, L. Coordinated Production and Utilization of FADH 2 by NAD(P)H−Flavin Oxidoreductase and 4-Hydroxyphenylacetate 3-Monooxygenase † . Biochemistry 2003, 42(24), 7509-7517 DOI: 10.1021/bi034092r
Dufresne, E.R.; Corwin, E.I.; Greenblatt, N.A.; Ashmore, J.; Wang, D.Y.; Dinsmore, A.D.; Cheng, J.X.; Xie, X.S.; Hutchinson, J.W.; Weitz, D.A. Flow and Fracture in Drying Nanoparticle Suspensions. Phys. Rev. Lett. 2003, 91(22) DOI: 10.1103/physrevlett.91.224501
Pautot, S.; Frisken, B.J.; Cheng, J.; Xie, X.S.; Weitz, D.A. Spontaneous Formation of Lipid Structures at Oil/Water/Lipid Interfaces. Langmuir 2003, 19(24), 10281-10287 DOI: 10.1021/la034532f
Nan, X.; Cheng, J.; Xie, X.S.X. Vibrational imaging of lipid droplets in live fibroblast cells with coherent anti-Stokes Raman scattering microscopy. The Journal of Lipid Research 2003, 44(11), 2202-2208 DOI: 10.1194/jlr.d300022-jlr200
Yang, H.; Luo, G.; Karnchanaphanurach, P.; Louie, T.; Rech, I.; Cova, S.; Xun, L.; Xie, X.S. Protein Conformational Dynamics Probed by Single-Molecule Electron Transfer. Science 2003, 302(5643), 262-266 DOI: 10.1126/science.1086911
Potma, E.O.; Xie, X.S. Detection of single lipid bilayers with coherent anti-Stokes Raman scattering (CARS) microscopy. J Raman Spectrosc 2003, 34(9), 642-650 DOI: 10.1002/jrs.1045
Potma, E.O.; Evans, C.; Xie, X.S.; Jones, R.J.; Ye, J. Picosecond-pulse amplification with an external passive optical cavity. Opt. Lett. 2003, 28(19), 1835 DOI: 10.1364/ol.28.001835
van Oijen, A.M.; Blainey, P.C.; Crampton, D.J.; Richardson, C.C.; Ellenberger, T.; Xie, X.S. Single-Molecule Kinetics of Exonuclease Reveal Base Dependence and Dynamic Disorder. Science 2003, 301(5637), 1235-1238 DOI: 10.1126/science.1084387
Cheng, J.; Pautot, S.; Weitz, D.A.; Xie, X.S. Ordering of water molecules between phospholipid bilayers visualized by coherent anti-Stokes Raman scattering microscopy. Proc. Natl. Acad. Sci. U.S.A. 2003, 100(17), 9826-9830 DOI: 10.1073/pnas.1732202100
Hartschuh, A.; Sánchez, E.J.; Xie, X.S.; Novotny, L. High-Resolution Near-Field Raman Microscopy of Single-Walled Carbon Nanotubes. Phys. Rev. Lett. 2003, 90(9) DOI: 10.1103/physrevlett.90.095503
Yang, H.; Xie, X.S. Probing single-molecule dynamics photon by photon. J. Chem. Phys 2002, 117, 10965 DOI:
Xie, X.S. Single-molecule approach to dispersed kinetics and dynamic disorder: Probing conformational fluctuation and enzymatic dynamics. J. Chem. Phys 2002, 117, 11024 DOI:
Yang, H.; Xie, X.S. Probing Single Molecule Dynamics Photon by Photon. J. Chem. Phys 2002, 117, 10965 DOI:
Sánchez, E.J.; Krug, J.T.I.; Xie, X.S. Ion and Electron Beam Assisted Growth of Nanometeric SimOn Structures for Near-Field Microscopy. Rev. Sci. Instr 2002, 73, 3901 DOI:
Luoie, T.M.; Yang, H.; Karnchanaphanurach, P.; Xie, X.S.; Xun, L. FAD is a Preferred Substrate and an Inhibitor of Escherichia coli General NAD(P)H: flavin Oxidoreductase. J. Biol. Chem 2002, 277, 39450 DOI:
Yang, H.; Xie, X.S. Statistical Approaches for Probing Single-molecule Dynamics Photon-by-Photon. Chem. Phys 2002, 284, 423 DOI:
Cheng, J.; Volkmer, A.; Book, L.D.; Xie, X.S. Multiplex Coherent Anti-Stokes Raman Scattering Microspectroscopy and Study of Lipid Vesicles. J. Phys. Chem. B 2002, 106, 8493 DOI:
Cheng, J.; Potma, E.O.; Xie, X.S. Coherent Anti-Stokes Raman Scattering Correlation Spectroscopy: Probing Dynamical Processes with Chemical Selectivity. J. Phys. Chem. A 2002, 106, 8561 DOI:
Jones, D.J.; Potma, E.O.; Cheng, J.; Burfeindt, B.; Pang, Y.; Ye, J.; Xie, X.S. Synchronization of two passively mode-locked, picosecond lasers within 20 fs for coherent anti-Stokes Raman scattering microscopy. Rev. Sci. Instrum 2002, 73, 2843 DOI:
Cheng, J.; Xie, X.S. Green's function formulation for third-harmonic generation microscopy. JOSAB 2002, 19, 1604 DOI:
Potma, E.O.; Jones, D.J.; Cheng, J.; Xie, X.S.; Ye, J. High-sensitivity coherent anti-Stokes Raman scattering microscopy with two tightly synchronized picosecond lasers. Optics Lett 2002, 27, 1168 DOI:
Cheng, J.; Jia, Y.K.; Zheng, G.; Xie, X.S. Laser-Scanning Coherent Anti-Stokes Raman Scattering Microscopy and Applications to Cell Biology. Biophys. J 2002, 83, 502 DOI:
Cheng, J.; Volkmer, A.; Xie, X.S. Theoretical and experimental characterization of coherent anti-Stokes Raman scattering microscopy. JOSA B 2002, 19, 1363 DOI:
Krug, J.T.I.; Sánchez, E.J.; Xie, X.S. Design of near-field probes with optimal field enhancement by finite difference time domain electromagnetic simulation. J. Chem. Phys 2002, 116(24), 10895 DOI:
Volkmer, A.; Book, L.D.; Xie, X.S. Time-resolved coherent anti-Stokes Raman scattering microscopy: Imaging based on Raman free induction decay. Appl. Phys. Lett 2002, 80, 1505 DOI:
Xie, S. Single-Molecule Approach to Enzymology. Single Mol. 2001, 2(4), 229-236 DOI: 10.1002/1438-5171(200112)2:4<229::aid-simo229>3.0.co;2-9
Cheng, J.; Book, L.D.; Xie, X.S. Polarization coherent anti-Stokes Raman scattering microscopy. Opt. Lett. 2001, 26(17), 1341 DOI: 10.1364/ol.26.001341
Volkmer, A.; Cheng, J.; Xie, X.S. Vibrational Imaging with High Sensitivity via Epidetected Coherent Anti-Stokes Raman Scattering Microscopy. Phys. Rev. Lett. 2001, 87(2) DOI: 10.1103/physrevlett.87.023901
Cheng, J.; Volkmer, A.; Book, L.D.; Xie, X.S. An Epi-Detected Coherent Anti-Stokes Raman Scattering (E-CARS) Microscope with High Spectral Resolution and High Sensitivity. J. Phys. Chem. B 2001, 105(7), 1277-1280 DOI: 10.1021/jp003774a
Schenter, G.K.; Lu, H.P.; Xie, X.S. Statistical Analyses and Theoretical Models of Single-Molecule Enzymatic Dynamics. J. Phys. Chem. A 1999, 103(49), 10477-10488 DOI:
Zumbusch, A.; Holtom, C.R.; Xie, X.S. Three-Dimensional Vibrational Imaging by Coherent Anti-Stokes Raman Scattering. Phys. Rev. Lett. 1999, 82, 4142-4145 DOI:
Xie, X.S.; Lu, H.P. Single-Molecule Enzymology. J. Biol. Chem 1999, 274, 15967 DOI:
Schenter, G.K.; Lu, H.P.; Xie, X.S. Statistical Analysis and Theoretical Models of Single-Molecule Enzymatic Dynamics. J. Phys. Chem. A 1999, 103, 10477 DOI:
Bai, C.; Wang, C.; Xie, X.S.; Wolynes, P.G. Single Molecule Physics and Chemistry. Proc. Natl. Acad. Sci. USA 1999, 96, 10477 DOI:
Zumbusch, A.; Holtom, G.R.; Xie, X.S. Vibrational Microscopy Using Coherent Anti-Stokes Raman Scattering. Phys. Rev. Lett 1999, 82, 4142 DOI:
Sánchez, E.J.; Novotny, L.; Xie, X.S. Near-field Fluorescence Microscopy Based on Two-Photon Excitation With Metal Tips. Phys. Rev. Lett 1999, 82, 4014 DOI:
Ying, L.; Xie, X.S. Optical Detection of Single Molecule and its Applications. Daxue Huaxue 1999, 14, 1 DOI:
Lu, H.P.; Xie, X.S. Single-Molecule Spectroscopy Studies of Molecular Dynamics in Chemical and Biological Systems. Z. Phys. Chem. (Muenchen) 1999, 212, 59 DOI:
Lu, H.P.; Xun, L.; Xie, X.S. Single Molecule Enzymatic Dynamics. Science 1998, 282, 1877 DOI:
Ying, L.; Xie, X.S. Fluorescence Spectroscopy, Excitation Dynamics and Photochemistry of Single Allophycocyanin Trimers. J. Phys. Chem. B 1998, 102, 10399 DOI:
Xie, X.S.; Trautman, J.K. Optical studies of single molecules at room temperature. Ann. Rev. Phys. Chem 1998, 49, 441 DOI:
Novotny, L.; Sanchez, E.J.; Xie, X.S. Near-field Optical Imaging Using Metal Tips Illuminated by Higher-order Hermite-Gaussian Beams. Ultramicroscopy 1998, 71, 21 DOI:
Sanchez, E.J.; Novotny, L.; Holtom, G.; Xie, X.S. Room-Temperature Fluorescence Imaging and Spectroscopy of Single Molecules by Two-Photon Excitation. J. Phys. Chem. A 1997, 101, 7019 DOI:
Novotny, L.; Bian, R.X.; Xie, X.S. Theory of Nanometric Optical Tweezers. Phys. Rev. Lett 1997, 79, 645 DOI:
Lu, H.P.; Xie, X.S. Single-Molecule Kinetics of Interfacial Electron Transfer Temperature. J. Phys. Chem 1997, 101, 2753 DOI:
Lu, H.P.; Xie, X.S. Single-Molecule Spectral Fluctuations at Room Temperature. Nature 1997, 385, 143 DOI:
Xie, X.S. Single-Molecule Spectroscopy and Dynamics at Room Temperature. Acc. Chem. Res 1996, 29, 598 DOI:
Bian, R.X.; Dunn, R.C.; Xie, X.S.; Leung, P.T. Single molecule emission characteristics in near-field microscopy. Phys. Rev. Lett 1995, 75, 4772 DOI:
Holtom, G.R.; Crowell, R.A.; Xie, X.S. A High Repetition Rate Femtosecond Optical Parametric Oscillator-Amplifier System Near 3 Microns. J. Optic. Soc. Am. B 1995, 12, 1723 DOI:
Dunn, R.C.; Xie, X.S. Characterization of the Temporal Behavior of Ultrashort Pulses Emerging from a Near-field Fiber Probe. Ultramicroscopy 1995, 57, 169 DOI:
Dunn, R.C.; Allen, E.V.; Joyce, S.A.; Anderson, G.A.; Xie, X.S. Near-field Fluorescent Imaging of Single Proteins. Ultramicroscopy 1995, 57, 113 DOI:
Crowell, R.A.; Holtom, G.R.; Xie, X.S. The Infrared Free Induction Decay of Liquid Water Molecules. J. Phys. Chem 1995, 99, 1840 DOI:
Xie, X.S.; Dunn, R.C. Probing Single Molecule Dynamics. Science 1994, 265, 361 DOI:
Crowell, R.A.; Holtom, G.R.; Xie, X.S. Liquid Water Dynamics Probed by Femtosecond Infrared Spectroscopy. Ultrafast Phenomena IX (Springer-Verlag) 1994, 156 DOI:
Xie, X.S.; Holtom, G.R.; Mets, L.; Dunn, R.C. Near-field Time-Resolved Spectroscopy on Single Molecules and Photosynthetic Membranes. Ultrafast Phenomena IX (Springer-Verlag) 1994, 124 DOI:
Dunn, R.C.; Holtom, G.R.; Mets, L.; Xie, X.S. Near-Field Fluorescence Imaging and Florescence Lifetime Measurements of Light Harvesting Complexes in Intact Photosynthetic Membranes. J. Phys. Chem 1994, 98, 3094 DOI: